Alzheimer Disease: A Self-Narrative Blog, "Watching The Lights Go Out"

A blog by Dr. David Hilfiker: Watching The Lights Go OutA Memoir from Inside Alzheimer's Disease
Source: BrainBlog - Category: Neurologists Source Type: blogs

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Authors: Elahifasaee F, Li F, Yang M Abstract Magnetic resonance (MR) imaging is a widely used imaging modality for detection of brain anatomical variations caused by brain diseases such as Alzheimer's disease (AD) and mild cognitive impairment (MCI). AD considered as an irreversible neurodegenerative disorder with progressive memory impairment moreover cognitive functions, while MCI would be considered as a transitional phase amongst age-related cognitive weakening. Numerous machine learning approaches have been examined, aiming at AD computer-aided diagnosis through employing MR image analysis. Conversely, MR bra...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
In this study, we concentrated on the activities on cognition, using an array of validated tests. We also performed lipidomic analyses of plasma, erythrocytes, and different brain areas. We report lower emotional memory (contextual fear conditioning) in aged rats supplemented with polar lipids’ concentrates from buttermilk or krill oil at doses that approximate human consumption. No other behavioral parameter was significantly influenced by the supplements calling for further research to confirm or not the purported salubrious activities of polar lipids, namely those rich in ω3 long-chain polyunsaturated fatty ...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Category: Lipidology Source Type: research
The objective of this work was to determine the effects of this drug on human erythrocytes, which have a type of AChE in the cell membrane. To that end, human erythrocytes and molecular models of its membrane constituted by dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE) were used. They correspond to classes of phospholipids present in the outer and inner monolayers of the human erythrocyte membrane, respectively. The experimental results obtained by X-ray diffraction and differential scanning calorimetry (DSC) indicated that rivastigmine molecules were able to interact with both phosph...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 20 February 2020Source: Journal of Molecular Graphics and ModellingAuthor(s): Rajneet Kaur Saini, Hema Thakur, Bhupesh GoyalAbstractThe amyloid-β (Aβ) aggregation in the brain has been associated with the development of Alzheimer's disease (AD). The previous studies have reported that Piedmont mutation (L34V) increases the rate of Aβ40 aggregation. However, the underlying molecular mechanism of the effect of L34V mutation on Aβ40 structure, dynamics, and aggregation remains largely unclear. In the present study, molecular dynamics (MD) simulations were performed to elu...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
AbstractAging is a crucial cause of cognitive decline and a major risk factor for Alzheimer ’s disease (AD); however, AD’s underlying molecular mechanisms remain unclear. Recently, tetraspanins have emerged as important modulators of synaptic function and memory. We demonstrate that the level of tetraspanin CD82 is upregulated in the brains of AD patients and middle-aged mice. In young adult mice, injection of AAV-CD82 to the hippocampus induced AD-like cognitive deficits and impairments in neuronal spine density. CD82 overexpression increased TRPM7 α-kinase cleavage via caspase-3 activation and induced N...
Source: AGE - Category: Geriatrics Source Type: research
AbstractAlzheimer ’s disease (AD) is the most common cause of dementia worldwide. AD is a multifactorial disease with simultaneous occurrence of several connected pathological processes including mitochondrial dysfunction and impaired proteostasis. Most of these are also implicated in organismal aging per se. The p resence of separable pathological conditions poses the opportunity to try combination treatments that target these different processes separately. This approach may provide an effective strategy to target AD; therefore, we investigated whether a combination of metformin (targeting mitochondria and e nergy ...
Source: AGE - Category: Geriatrics Source Type: research
Molecules, Vol. 25, Pages 985: Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease Molecules doi: 10.3390/molecules25040985 Authors: Chaves Resta Rinaldo Costa Josselin Gwizdala Piemontese Capriati Pereira-Santos Cardoso Santos : A series of multi-target-directed ligands (MTDLs), obtained by attachment of a hydroxyphenylbenzimidazole (BIM) unit to donepezil (DNP) active mimetic moiety (benzyl-piperidine/-piperazine) was designed, synthesized, and evaluated as potential ant...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Molecules, Vol. 25, Pages 982: Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease Molecules doi: 10.3390/molecules25040982 Authors: Cassis Varlow Emily Murrell Jason P. Holland Alina Kassenbrock Whitney Shannon Steven H. Liang Neil Vasdev Nickeisha A. Stephenson [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing challenge. Herein, five metal-free p...
Source: Molecules - Category: Chemistry Authors: Tags: Communication Source Type: research
AbstractAlzheimer ’s disease (AD) is a complex genetic disorder. To date, published data have reported conflicting results on the role of CD33 rs3865444 polymorphism in AD. The present study aimed at evaluating the effect of rs3865444 on AD in a large cohort of Greek native patients with AD. We also conducted a met a-analysis by pooling information from different studies on the same topic. Patients with AD (n = 327) and healthy controls (n = 327) were analyzed and genotyped for rs3865444. Single locus analyses were run to explore possible associations betweenCD33 rs3865444 polymorphism and...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
ConclusionsCustomized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
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