Chronic alcohol consumption enhances skeletal muscle wasting in mice bearing cachectic cancers: the role of TNF α/myostatin axis.

CONCLUSIONS: Chronic alcohol consumption enhances cancer-associated skeletal muscle loss through suppressing Akt/mTOR-mediated protein synthesis pathway and enhancing protein degradation pathways. This process is initiated by TNFα and mediated by myostatin. PMID: 31657476 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31657476?dopt=Abstract

Source: Alcoholism, Clinical and Experimental Research - October 27, 2019 Category: Addiction Authors: Li Y, Zhang F, Modrak S, Little A, Zhang H Tags: Alcohol Clin Exp Res Source Type: research