Human Pluripotent Stem Cells for Spinal Cord Injury.

Human Pluripotent Stem Cells for Spinal Cord Injury. Curr Stem Cell Res Ther. 2019 Oct 18;: Authors: Forouzesh M, Hosseini M, Farzaneh M, Azarshab M, Anbiyaiee A, Khoshnam SE Abstract Spinal cord injury (SCI) as a serious public health issue and neurological insult is one of the most causes of long-term disability. To date, a variety of techniques have been widely developed to treat central nervous system injury. Currently, clinical treatments are limited to surgical decompression and pharmacotherapy. Because of their negative effects and inefficiency, novel therapeutic approaches in the management of SCI are required. Improvement and innovation of stem cell-based therapies have allowed a huge potential for biological and future clinical applications. Human pluripotent stem cells (hPSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are defined by their abilities to divide asymmetrically, self-renew and ultimately differentiate into various cell lineages. There are considerable research efforts to use various types of stem cells such as ESCs, neural stem cells (NSCs), and mesenchymal stem cells (MSCs) in the treatment of patients with SCI. Moreover, the use of patient-specific iPSCs hold great potential as an unlimited cell source for generating in vivo models of SCI. In this review we focused on the potential of hPSCs in treating SCI. PMID: 31656156 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research