Seeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of Arginine Analogs Inhibiting CASTOR1

Conclusion: Norarginine and Nα-acetyl-arginine are the top drug candidates for mTORC1 inhibition, with Nα-acetyl-arginine being the best choice.

Source: Cancer Genomics and Proteomics - October 27, 2019 Category: Cancer & Oncology Authors: SUN, L., LI, X., PAN, J., MAO, J., YUAN, Y., WANG, D., SUN, W., KRUEGER, G. R. F., WANG, G. Tags: Article Source Type: research