How Common Are Gastric Ulcers?

Discussion The exact cause of gastric and upper intestinal inflammation and ulceration are not entirely understood. Imbalances between irritative factors and mucosal defenses underlie it. Gastric acid production is at adult levels by 3-4 years. Actual ulceration is associated with a lower acid secretion for gastric ulcerations but are increased in duodenal ulcerations in both adults and children. In adults changes to the mucus layer of the stomach and duodenum and bicarbonate secretion play a part in upper GI inflammation and ulcerations. Genetic studies have been linked to differences in both acid production, and mucosal barriers. Additionally there may also be genetic differences linked to Helicobacter pylori (H. pylori) infections. H. pylori infections are linked to overcrowding and poor socioeconomic conditions, but rates appear to be declining across the world. Primary ulcerations are defined as upper GI ulcerations in pediatric patients that have no other identified etiology. They are most often caused by H. pylori infection in children. They are much less frequent than secondary ulcerations. Secondary ulcers are due to other causes of upper GI inflammation such as trauma, sepsis, or drugs (i.e. non-steroidal anti-inflammatory drugs), but they can also occur as a secondary problem in specific diseases such as Crohn’s disease and Zollinger-Ellison syndrome. Sickle-cell anemia, reactivation of viral infections such as Epstein-Barr and Varicella infections, and cyst...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news