The Impact of Hepatitis C Virus Infection on Buprenorphine Dose in Pregnancy

Conclusion Women with HCV infection required less of an increase in BUP dose throughout pregnancy compared with women without HCV infection. Severity of HCV infection, as measured by viral load and liver enzymes, was also associated with BUP dosing. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: SMFM 2019 Source Type: research

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The objectives of this study were to compare the PK parameters of ledipasvir/sofosbuvir (LDV/SOF) in pregnant versus nonpregnant women, and to assess adverse events and viral response.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
CONCLUSION: A high proportion of reproductive-aged women with newly diagnosed HCV infection were pregnant. Surveillance-informed outreach to this population was feasible and provided opportunities for counseling and linkage to confirmatory testing and treatment. Future studies should evaluate whether a similar model would enhance testing and linkage to care of HCV-exposed infants. PMID: 31738858 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
Conclusions: NC OTPs are a logical setting for integrating RSH services to meet the needs of reproductive-age women in treatment for OUD.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research
Abstract Hepatitis C virus (HCV) is transmitted primarily through parenteral exposures to infectious blood or body fluids that contain blood (e.g., via injection drug use, needle stick injuries) (1). In the last 10 years, increases in HCV infection in the general U.S. population (1) and among pregnant women (2) are attributed to a surge in injection drug use associated with the opioid crisis. Opioid use disorders among pregnant women have increased (3), and approximately 68% of pregnant women with HCV infection have opioid use disorder (4). National trends in HCV infection among pregnant women by opioid use disord...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Opioid use disorder and hepatitis C virus infection rates significantly increased during 2000-2015 among women delivering in hospitals in the United States.
Source: CDC Morbidity and Mortality Weekly Report - Category: American Health Tags: Hepatitis C Hospitalization rates MMWR Morbidity & Mortality Weekly Report Pregnancy Opioids Source Type: news
Abstract Ethiopia's hepatitis virus (HCV) prevalence is predicted to rise by 2030. To halt this increasing trend, a suitable approach to the elimination of HCV is needed. This review explores the current status, challenges, and opportunities and outlines a strategy for the micro-elimination approach in Ethiopia. I searched PubMed and EMBASE using combined Medical Subject Heading databases for the literature on HCV micro-elimination. A phased public health approach to HCV micro-elimination, including preparation/capacity building (phase I), implementation (phase II), and rollout and scale-up (phase III), targeting ...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
Conclusion: A significant proportion of pregnant women have anti-HBs while the seroprevalence of HCV is low among pregnant women in the city of Mwanza. Routine screening of HBV among pregnant women coupled with appropriate management should be emphasized in developing countries. Further studies to determine seroprevalence of HCV are recommended across the country. PMID: 31316835 [PubMed - in process]
Source: Journal of Pregnancy - Category: OBGYN Tags: J Pregnancy Source Type: research
In conclusion, approximately 2% of pregnant women in the study population were known to have been exposed to HCV by the time of their delivery. One-third of women with documented drug abuse did not have an HCV test during pregnancy, revealing gaps in HCV testing of pregnant women. Further studies are needed to understand the full costs and benefits of risk-based screening versus universal screening in this and other populations. PMID: 31275902 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
In a recent issue of Digestive and Liver Disease, Lembo et al. [1] presented an interesting survey on hepatitis B and hepatitis C prevalence in pregnancy in Southern Italy. Regarding hepatitis B virus (HBV), analyzing a cohort of 7,558 pregnant women, a prevalence of 0.5% was reported. Hepatitis B surface Antigen (HBsAg) seroprevalence was significantly higher among the 569 foreigners compared to the 5,559 Italian women (3% vs. 0.2%, p  
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Correspondence Source Type: research
(Joule Inc.) Hepatitis C virus (HCV) transmission from mothers to babies could largely be prevented if Canada recommended universal screening for HCV in pregnancy, argues a commentary in CMAJ (Canadian Medical Association Journal).
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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