Anti-inflammatory effect of epidermal growth factor conjugated silk fibroin immobilized polyurethane ameliorates diabetic burn wound healing.

In this study, PU/SF (Antheraea mylitta) scaffolds were fabricated by blending and immobilization techniques. Effective SF dosage was determined and incorporated according to minimum inhibitory concentrations against wound associated bacterial strains while fabricating scaffold. Dermal fibroblast NIH3T3 cells were seeded on epidermal growth factor (EGF) treated and untreated PU/SF scaffolds, fabricated by blending and immobilization techniques. Fibroblast seeded PU/SF scaffolds were investigated for anti-inflammatory response in wound recovering potential comparing with ActicoatTM in third degree burn of streptozotocin induced diabetic rats. At 16th, 24th days, promising healing was achieved with faster granulation, enhanced collagenization, patterned re-epithelialization by EGF treated cellular immobilized PU/SF in normal, hyperglycemic burn. Biomarkers of different healing stages, CD31 (haemostasis), Ki67 (proliferative), alpha-sma, COL III (maturation) were examined. Since hyperglycemic burn is characterized by inflated pro-inflammatory cytokines, serum, tissue IL-6,8,10 were recorded, which revealed timely restoration of inflated IL-6,8, protection against IL-10 elevation by cellular immobilized PU/SF compared to ActicoatTM (p≤0.05), control (p≤0.01). E-cadherin (gap junction protein), MMP 9 response suggested anti-inflammatory role of PU/SF on accelerated healing of thermal injury as potent dermal substitute. PMID: 31647938 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research

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Honey with tea, toast, apples and oatmeal – that all sounds normal and delicious. Honey on wounds, though? It may sound a little out of the ordinary, but honey has actually helped wounds heal for thousands of years. While there are plenty of advanced healing tools available today, honey's antibacterial properties and unique pH balance still make it a helpful treatment for certain wounds. Here's what to know about using honey for healing wounds: Honey has powerful healing properties. The type of honey Wound-care professionals typically use medical-grade honey for healing chronic wounds, although Manuka ...
Source: Advanced Tissue - Category: Dermatology Authors: Tags: Wound healing Wound care products Source Type: news
Visceral fat is also known as belly fat and is found inside your abdominal cavity. Carrying too much visceral fat is extremely harmful for one's health. It's linked to a higher risk of type 2 diabetes, insulin resistance, heart disease and even certain cancers. A popular diet which has gained much notoriety could be key in helping you lose your visceral fat.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
A 71-year-old Jehovah ’s witness woman with a past medical history significant for diabetes mellitus, hypertension, breast cancer, aortic stenosis, and coronary artery disease underwent three-vessel coronary artery bypass graft (CABG) and surgical aortic valve replacement (SAVR) with a 19 mm Sorin Mitroflow (Sorin Grou p, CO, USA) (True internal diameter 15.4 mm). Severe patient prosthesis mismatch (PPM) (EOAi: 0.30 cm2/m2) was diagnosed shortly after surgery with post-operative mean gradients of 40 mmHg by echocardiography.
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Tags: Case report Source Type: research
Publication date: Available online 18 July 2020Source: Canadian Journal of DiabetesAuthor(s): Richard E. Gilbert, Lauren Caldwell, Paraish S. Misra, Kin Chan, Kevin D. Burns, Jeffrey L. Wrana, Darren A. Yuen
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
ConclusionsWe did not find enough reliable evidence to find out whether a tax on the fat content of foods resulted in people eating less fat, or less saturated fat.We did not find any evidence about how a tax on the fat content of foods affected obesity or overweight.The results of our review will change when further evidence becomes available.Discussing the findings of this review, lead author Stefan Lhachimi said, “A tax on saturated fats could be in principle a good approach to reduce the consumption of so-called junk foods, a group of food products which is fiendishly tricky to define in legal terms. By taxing a ...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
This report provides an overview of information that was presented and the subsequent guided discussions. PMID: 32857831 [PubMed - as supplied by publisher]
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
Authors: Berlanga-Acosta J, Camacho-Rodríguez H, Mendoza-Marí Y, Falcón-Cama V, García-Ojalvo A, Herrera-Martínez L, Guillén-Nieto G Abstract Lower-extremity diabetic ulcers are responsible for 80% of annual worldwide nontraumatic amputations. Epidermal growth factor (EGF) reduction is one of the molecular pillars of diabetic ulcer chronicity, thus EGF administration may be considered a type of replacement therapy. Topical EGF ad-ministration to improve and speed wound healing began in 1989 on burn patients as part of an acute-healing therapy. Further clinical studies based...
Source: MEDICC Review - Category: International Medicine & Public Health Tags: MEDICC Rev Source Type: research
Publication date: Available online 15 August 2020Source: BurnsAuthor(s): Walid Kamal Abdelbasset, Shereen H. Elsayed, Gopal Nambi, Sayed A. Tantawy, Dalia M. Kamel, Marwa M Eid, Samah A. Moawd, Saud F. Alsubaie
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 5 August 2020Source: BurnsAuthor(s): Jason Diab, Justine O’Hara, Miranda Pye, Christine Parker, Peter K.M. Maitz, Andrea Issler-Fisher
Source: Burns - Category: Dermatology Source Type: research
By HANS DUVEFELT, MD Now that we are seeing patients via telemedicine or even getting reimbursed for handling their issues over the phone, our existing healthcare institutions are more and more starting to look like shopping malls.  They were once traffic magnets, so large that they created new developments far away from where people lived or worked and big and complex enough that going there became an all day affair for many people.  What this pandemic has brought us is a shift in our view of where you have to be in order to get things done. If you can earn your wage remotely and still buy things online...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: COVID-19 Medical Practice Source Type: blogs
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