Simulating cerebral edema and delayed fatality after traumatic brain injury using triphasic swelling biomechanics.

Conclusion: To the best of our knowledge, this is the first study to simulate post-traumatic brain swelling to predict outcome. By incorporating swelling, ischemia, and cell death, our novel approach may improve fidelity of predicting outcome after MVCs. A strength of our approach is relying on the validated GHBMC model to predict brain deformation in the crash-scenario. The main goal of the current study was to demonstrate feasibility of simulating post-injury swelling using triphasic biomechanics. We successfully predicted clinically relevant increases in ICP that suggest a high likelihood of death when simulating a fatal impact scenario, however, more validation of our methodology is needed. PMID: 31647331 [PubMed - as supplied by publisher]
Source: Traffic Injury Prevention - Category: Accident Prevention Authors: Tags: Traffic Inj Prev Source Type: research