Lassa Fever

Lassa fever outbreaks West Africa have caused up to 10,000 deaths annually. Primary infection occurs from contact with Lassa virus-infected rodents and exposure to their excreta, blood, or meat. Incubation takes 2 to 21  days. Symptoms are difficult to distinguish from malaria, typhoid, dengue, yellow fever, and other viral hemorrhagic fevers. Clinical manifestations range from asymptomatic, to mild, to severe fulminant disease. Ribavirin can improve outcomes. Overall mortality is between 1% and 15%. Lassa fever s hould be considered in the differential diagnosis with travel to West Africa. There is an urgent need for rapid field-friendly diagnostics and preventive vaccine.
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Source Type: research

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Date: Tuesday, 01 07, 2020; Speaker: Daniel Neafsey, Assistant Professor, Harvard T.H. Chan School of Public Health; 5625 Fishers Lane; 5th Floor Conference Room
Source: NIH Calendar of Events - Category: American Health Source Type: events
Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
Conclusion: The 2017 dengue outbreak occurred in a larger scale than in the previous years in terms of time, location, and number of patients. More elderly patients were infected by dengue in this outbreak, and this may contribute to the mortality rate. Clinical manifestations of dengue patients in Southern Vietnam are more typical than the northern, but the rate of severe dengue is not different. The mortality risk and underlying conditions associated with dengue-infected elderly patients are worthy of further investigations in the future. PMID: 31815129 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Qishuo Wang, Tianzeng Fu, Xincang Li, Qian Luo, Jinjing Huang, Yongcan Sun, Xuepeng WangAbstractStreptococcus agalactiae and Streptococcus iniae are major bacterial pathogens of tilapia that can cause high mortality concomitant with large economic losses to aquaculture. Although development of vaccines using formalin-killed bacteria to control these diseases has been attempted, the mechanism of immunity against streptococcal infections and the cross-protective ability of these two bacteria remains unclear. To explore the imm...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 10 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Lu Li, Ming Song, Bo Peng, Xuan-xian Peng, Hui LiAbstractOne of the most important emerging pathogens in the aquaculture industry is Edwardsiella tarda, and it causes extensive losses in farmed fish globally. The identification of protective immunogens against E. tarda is increasingly valued. We previously investigated 20 recombinant proteins of 38 E. tarda extracellular secretory proteins and identified 10 as protective immunogens in a zebrafish model. Here, we clone 10 of the remaining 18 genes, and the resulting recombina...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 9 December 2019Source: Fish &Shellfish ImmunologyAuthor(s): Jianlin Chen, Zhenwei Chen, Wenji Wang, Suying Hou, Jia Cai, Liqun Xia, Yishan LuAbstractNocardia seriolae, a Gram-positive pathogen, has been identified as the causative agent of fish nocardiosis. DNA vaccination has been proven to be effective in conferring protection against bacterial infection in fish. The 30S ribosomal protein S1 (RpsA) and 50S ribosomal protein L7/L12 (RplL) were identified to be the common immunodominant antigens of three fish pathogenic Nocardia (N. seriolae, N. salmonicida and N. asteroids) by immuno...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
The Theranos fiasco (see:The rise and fall of Theranos, the blood-testing startup that went from Silicon Valley darling to facing fraud charges) served to cast a pall over the micro-sample diagnostics market. Now comes news about an Israeli company with a similar strategy but this time with an instrument providing a complete blood count (CBC) and a green light from the FDA (see:Unlike Theranos, startup ’s blood test device ‘delivers on promise’ with FDA nod). Below is an excerpt from the article:Israeli startupSight Diagnostics has received US Food and Drug Administration clearance to market a blood ...
Source: Lab Soft News - Category: Laboratory Medicine Authors: Tags: AI Clinical Lab Testing Diagnostics Food and Drug Administration Healthcare Information Technology Healthcare Innovations Medical Research Point-of-Care Testing Source Type: blogs
This outbreak is caused by a different strain of E. coli than the other current outbreak linked to romaine lettuce grown in the Salinas, California region, which has over 100 reported cases of infection.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Studies focused on development of an attenuated vaccine against Mycobacterium avium subsp. paratuberculosis (Map), the causative agent of paratuberculosis (Ptb) in cattle and other species, revealed that deletion of relA, a global gene regulator, abrogates the ability of Map to establish a persistent infection. In the absence of relA, cattle develop CD8 cytotoxic T cells (CTL) with the ability to kill intracellular bacteria. Analysis of the recall response to a relA mutant, Map/ΔrelA, with cells from a vaccinated steer demonstrated that a 35-kDa membrane peptide (MMP) is one of the targets of the response. This obser...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Public Health England has said that the risk to public health is very lowCases ofbird flu have been confirmed at a chicken farm in Suffolk, the government has said.All 27,000 birds at the commercial farm will be culled after a number were found to have the H5 type of avian flu, the Department for Environment, Food and Rural Affairs said on Tuesday.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Agriculture Bird flu Health Science Society UK news Source Type: news
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