Ebola Virus Disease

This article highlights the epidemiology, clinical features, diagnosis, management, and prevention of EVD. The emerging diagnostic technologies, rapid viral characterization, geospatial mapping of EVD transmission, and new treatments and vaccines are discussed.
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Source Type: research

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Darwyn Kobasa Ebola virus (EBOV) is a zoonotic pathogen that poses a significant threat to public health, causing sporadic yet devastating outbreaks that have the potential to spread worldwide, as demonstrated during the 2013–2016 West African outbreak. Mouse models of infection are important tools for the development of therapeutics and vaccines. Exposure of immunocompetent mice to clinical isolates of EBOV is nonlethal; consequently, EBOV requires prior adaptation in mice to cause lethal disease. Until now, the only immunocompetent EBOV mouse model was based on the Mayinga variant, which was isolated in 1...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Abstract In this two-part series of reviews, we have invited experts in their fields to contribute articles on the status of vaccine research and development for emerging pathogens. This topic has been brought into sharp focus in recent years following significant outbreaks of viral diseases such as those causing severe acute respiratory syndrome and Middle East respiratory syndrome, as well as devastating outbreaks of diseases caused by the Ebola, Marburg, Zika and Lassa fever viruses, to name only a few examples. Additionally, bacterial infections leading to bubonic and pneumonic plague, most notably in Madagasc...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
Abstract The West African Ebola virus (EBOV) epidemic has fast-tracked countermeasures for this rare, emerging zoonotic pathogen. Until 2013-2014, most EBOV vaccine candidates were stalled between the preclinical and clinical milestones on the path to licensure, because of funding problems, lack of interest from pharmaceutical companies, and competing priorities in public health. The unprecedented and devastating epidemic propelled vaccine candidates toward clinical trials that were initiated near the end of the active response to the outbreak. Those trials did not have a major impact on the epidemic but provided ...
Source: Annual Review of Microbiology - Category: Microbiology Authors: Tags: Annu Rev Microbiol Source Type: research
James McGrane, FAO ECTAD Indonesia Team Leader, at his office in Jakarta. Credit: Kanis Dursin/IPSBy Kanis DursinJAKARTA, Indonesia, Jul 10 2017 (IPS)Poultry farmer Bambang Sutrisno Setiawan had long heard about biosecurity but never gave serious thought to it, even when the highly pathogenic avian influenza H5N1 forced him to cull thousands of his layer chickens in 2003 and 2009.Eighteen years into the business, however, Bambang, who is called Ilung by friends, is now converting his second farm into a three-zone biosecurity poultry with a strong conviction that it is the only way to save his business amid continued threat...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Asia-Pacific Economy & Trade Featured Food & Agriculture Headlines Health Projects avian flu biosafety Food and Agriculture Organization of the United Nations (FAO) Improving the lives of rural populations: better nutrition & agricultu Source Type: news
Abstract Ebola virus disease (EVD) is a threat to human health and to the survival of African great apes. The disease has led to major population declines in chimpanzees Pan troglodytes and gorillas Gorilla gorilla, and infected great apes play an important role as sources of human EVD outbreaks. The threat posed by EVD raises the question whether vaccination of wild apes is an effective strategy to reduce the occurrence and impact of this disease. We review the current knowledge about EVD in great apes and document the link between outbreaks in apes and in humans, mainly via bushmeat consumption. We discuss the need fo...
Source: Mammal Review - Category: Zoology Authors: Tags: Review Source Type: research
CONCLUSIONS The urge to do something to help in an international medical crisis is understandable and admirable, but the adverse impacts reported by participants here – at every stage of deployment, suggest that preparedness for these missions needs improvement and at the very least, high risk missions should be limited to more seasoned and well trained (for conditions in the field) personnel. While volunteering for a medical mission during a health crisis can be very rewarding, both professionally and personally, it can also be very disruptive and impactful. All volunteers for high risk missions must be made fully a...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
AbstractCapps and Lederman, in a paper published in this journal in 2015, argued that, at the time, the dismal circumstances of the Ebola outbreak in West Africa was an opportunity to revisit public health responses to emergent infectious diseases. Using a One Health lens, they argued for an ecological perspective —one that looked to respond to zoonoses as an environmental as well as public health concern. Using Ebola virus disease as an example, they suggested shared immunity as a strategy to vaccinate both humans and great apes. Since then, vaccination as a conservation strategyin this case has been debated and at ...
Source: Journal of Agricultural and Environmental Ethics - Category: Medical Ethics Source Type: research
Epidemiology&Infection, Volume 144 Issue 12 Epidemiology&Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy and ...
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
Public health officials are growing more and more concerned about the Zika virus as its true impact in South and Central America becomes clear. In January, the World Health Organization said Zika could be on the verge of spreading throughout the Americas. Health organizations in the U.S. are upping their efforts to develop a vaccine and eradicate the virus, and the White House has asked that money be appropriated to help make this happen. But as certain as death and taxes, Republicans in the House of Representatives have emerged to slow this process to a crawl. GOP lawmakers have met these calls to action with indifference...
Source: Science - The Huffington Post - Category: Science Source Type: news
Epidemiology &Infection, Volume 144 Issue 07 Epidemiology &Infection publishes original reports and reviews on all aspects of infection in humans and animals. Particular emphasis is given to the epidemiology, prevention and control of infectious diseases. The scope covers the zoonoses, outbreaks, food hygiene, vaccine studies, statistics and the clinical, social and public-health aspects of infectious disease, as well as some tropical infections. It has become the key international periodical in which to find the latest reports on recently discovered infections and new technology. For those concerned with policy an...
Source: Epidemiology and Infection - Category: Epidemiology Source Type: research
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