Proteasome Activation by Insulin ‐like Growth Factor‐1/Nuclear Factor Erythroid 2‐related Factor 2 Signaling Promotes Exercise‐induced Neurogenesis

This study shows that voluntary exercise causes hippocampal proteasome activation to improve adult neural progenitor cells activity. Mechanistically, exercise induces the increase of insulin like growth factor 1 (IGF ‐1) in serum and hippocampus, which in turn triggers the nuclear translocation of nuclear factor erythroid 2‐related factor 2 (Nrf2) to promote the expression of the key proteasome subunit PSMB5 to enhance adult neurogenesis. This finding reveals novel insights into the modulation of adult neuro genesis through proteasome activation, which could be achieved by targeting the IGF‐1/Nrf2 signaling pathway.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research