Does MRI trump pathology? An new era for staging and monitoring of kidney fibrosis
Renal fibrosis, which is characterised by the progressive deposition and accumulation of excess extracellular matrix (1), is a strong predictor of progression in chronic kidney disease (CKD)(2)(3). Recent advances in diagnostic imaging techniques, including ultrasonography and non contrast-enhanced magnetic resonance imaging (MRI), have shown promise for non-invasive assessment of renal fibrosis both in animals and humans.(4) However, the specificity of these techniques is controversial, as they indirectly assess renal fibrosis by evaluating the impact on mechanical or molecular properties of the tissue, and in the case of functional MRI, on kidney function.
Source: Kidney International - Category: Urology & Nephrology Authors: Anna Caroli, Andrea Remuzzi, Giuseppe Remuzzi Tags: Nephrology Digest Source Type: research
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