Short Versus Extended Progesterone Supplementation for Luteal Phase Support in fresh IVF cycles: a systematic review and meta-analysis
Publication date: Available online 24 October 2019Source: Reproductive BioMedicine OnlineAuthor(s): M Watters, M Noble, T Child, SM NelsonAbstractThis review and meta-analysis aims to assess the effect of prolonged progesterone support on pregnancy outcomes in women undergoing a fresh embryo transfer after IVF/ICSI.Two independent reviewers searched EMBASE, MEDLINE and grey literature from inception to January 2019 for RCTs of prolonged progesterone support vs early cessation. Risk of bias was assessed. Outcome measures were live birth, miscarriage and ongoing pregnancy rate. Study protocol CRD42018088605.Seven trials involving 1,627 participants were included: 3 reported live birth rate with 672 livebirths in 830 participants, 7 the miscarriage rate with 178 miscarriages in 1,627 participants and 7 the ongoing pregnancy with 1,351 ongoing pregnancies in 1,627 participants. Clinical outcomes were similar between early progesterone cessation vs progesterone continuation: live birth rate (RR: 0.94, 95% CI: 0.84-1.00), miscarriage rate (RR: 0.91, 95% CI: 0.69-1.20), ongoing pregnancy rate (RR: 0.98, 95% CI:0.91-1.05). Ongoing pregnancy rates were similar when we restricted analyses to those with randomization on the day of a positive hCG (RR: 0.93, 95% CI 0.83, 1.06).This meta-analysis suggests that prolonged progesterone support may be unnecessary after fresh embryo transfer. Further larger RCTs would be useful to corroborate and lead to standardised duration of progesterone lu...
CONCLUSIONS: While avoiding unnecessary embryo transfers and miscarriages are important goals, patients and doctors need to be aware of the high cost implications of applying PGT-A using aCGH on polar bodies. FUNDING: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The ESTEEM study was funded by the European Society for Human Reproduction and Embryology. Illumina provided microarrays and other consumables necessary for aCGH testing of polar bodies. PMID: 31930663 [PubMed - as supplied by publisher]
ConclusionsAOA was able to “rescue” the poor reproductive outcomes in certain types of infertile couples with history of failure pregnancy.
CONCLUSION: MCDA twins after IVF/ICSI have lower overall survival rates and higher rates of second-trimester miscarriage compared to spontaneously conceived MCDA twins. This article is protected by copyright. All rights reserved. PMID: 31909558 [PubMed - as supplied by publisher]
CONCLUSIONS: UtA-PI and proportion of SGA are lower in pregnancies after frozen as compared to fresh blastocyst transfer. This article is protected by copyright. All rights reserved. PMID: 31909549 [PubMed - as supplied by publisher]
ConclusionsChromosomal aberrations and aneuploidy manifested specific characteristics that differed between TEs and SA-CVBs, which indicates that distinct chromosomal abnormalities can affect certain developmental stages of embryos. Further analysis is needed to explore the chromosomal mechanisms affecting embryo development and implantation. Such information will help clinical assessments in prenatal diagnosis and reduce the incidence of genetically abnormal fetuses.
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in patients with poor ovarian response undergoing in vitro fertilization/intracytoplasmic sperm injection with a gonadotropin-releasing hormone antagonist protocol, although significantly higher serum insulin-like growth factor-1 level and insignificantly lower serum insulin-like growth factor binding protein-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment. (Curr Ther Res Clin Exp. 2020; 81:XXX–XXX)
Conclusions: Women undergoing IVF/ICSI with a previous CS have a lower live birth rate and a higher miscarriage rate than those with a previous VD.
Authors: Yang DN, Wu JH, Geng L, Cao LJ, Zhang QJ, Luo JQ, Kallen A, Hou ZH, Qian WP, Shi Y, Xia X Abstract This meta-analysis was intended to evaluate the effects of intrauterine perfusion of peripheral blood mononuclear cells (PBMC) on the pregnancy outcomes including clinical pregnancy rates, embryo implantation rates, live birth rates and miscarriage rates of infertile women who were undergoing in vitro fertilisation (IVF) treatment. By searching Pubmed, Embase database, five articles meeting the inclusion criteria were included, and 1173 women were enrolled (intrauterine PBMC group: n = 514; NO-P...
Conclusionshp-HMG and rFSH did not lead to significantly different treatment outcomes in POR patients undergoing IVF/ISCI with a GnRH antagonist protocol, although significantly higher serum IGF-1 level and insignificantly lower serum IGFBP-1 level on the day of oocyte retrieval associated with hp-HMG might suggest a beneficial endocrine environment.
Publication date: Available online 23 November 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Mauro Cozzolino, Jason Franasiak, Alessandra Andrisani, Guido Ambrosini, Amerigo VitaglianoAbstractTo evaluate the effectiveness of delay start protocol in improving the success of in vitro fertilization (IVF) in poor responders according to Bologna’s criteria. Only randomized controlled trial (RCT) of infertile women undergoing a single IVF/ICSI cycle with ovarian stimulation protocol based on daily injections with delay start protocol or a conventional antagonist protocol were...