Insertion of beta-alanine in model peptides for copper binding to His96 and His111 of the human prion protein.

This study clearly shows that two main factors determine the nature of Cu(II)-peptide complexes involving an anchoring His residue and deprotonated amides from the backbone chain: i) the stabilization of Cu(II)-peptide complexes due to the formation of cyclic structures (i.e. chelate effect) and ii) the nature of the residues associated to the deprotonated amide groups that participate in metal ion coordination.
PMID: 23796442 [PubMed - as supplied by publisher]

Source: Journal of Inorganic Biochemistry - June 5, 2013 Category: Biochemistry Authors: Rivillas-Acevedo L, Maciel-Barón L, García JE, Juaristi E, Quintanar L Tags: J Inorg Biochem Source Type: research