Efficacy and Safety of the Local Application of Mitomycin C to Recurrent Esophageal Strictures in Children

Objectives: Research on long-term use of mitomycin C (MC) for recurrent esophageal stenoses is limited. We assessed the long-term efficacy and safety of local application of MC for recurrent esophageal stenoses in children. Methods: This was a retrospective study of 39 patients (17 girls) with a median age of 19.5 months (range: 2.4–196.0) at the time of MC application. The etiologies of stenosis were esophageal atresia (n = 25), caustic ingestion (n = 9), congenital esophageal stenosis (n = 3), and other causes (n = 2). Stenosis was single in 35 (90%) patients and multiple in 4 (10%). Before MC, patients underwent multiple repeated dilations (median: 3 dilations per child [range: 2–26]) over a median period of 7 months (range: 2.6–49.3). Treatment success was defined a priori as a reduction in the number of dilations over the same period from before to after the application of MC. Results: For 26 (67%) patients, the application of MC was considered a success: 102 versus 17 dilatations (P 
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research