Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice.

Source: Journal of Neuroimmunology - October 23, 2019 Category: Allergy & Immunology Authors: Nataliia Sergeevna Novikova, Anastasiia Sergeevna Diatlova, Kristina Zurabovna Derevtsova, Elena Andreevna Korneva, Fedotkina Tamara Viktorovna, Yuri Ostrinki, Lital Abraham, Shir Quinn, Yahel Segal, Leonid Churilov, Miri Blank, Yehuda Shoenfeld, Rina Aha Source Type: research