Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells

This study demonstrates that Canonical Wnt signaling promotes cardiac pacemaker lineage from Flk1+/PdgfR ‐α+ cardiac progenitors. Thede novo pacemaker cells exhibit hallmark features of native cardiac pacemaker cells, attesting to their therapeutic potential for cardiac rhythm ‐related diseases.

Source: Stem Cells - October 23, 2019 Category: Stem Cells Authors: Wenbin Liang, Pengcheng Han, Elizabeth H. Kim, Jordan Mak, Rui Zhang, Angelo G. Torrente, Joshua I. Goldhaber, Eduardo Marb án, Hee Cheol Cho Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research