Process development for pandemic influenza VLP vaccine production using a baculovirus expression system

Influenza viruses cause hundreds of thousands of respiratory diseases worldwide each year, and vaccination is considered the most effective approach for preventing influenza annual epidemics or pandemics. Sinc...
Source: Journal of Biological Engineering - Category: Biotechnology Authors: Tags: Research Source Type: research

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Publication date: Available online 12 June 2019Source: EpidemicsAuthor(s): Timothy C. Germann, Hongjiang Gao, Manoj Gambhir, Andrew Plummer, Matthew Biggerstaff, Carrie Reed, Amra UzicaninAbstractWe used individual-based computer simulation models at community, regional and national levels to evaluate the likely impact of coordinated pre-emptive school dismissal policies during an influenza pandemic. Such policies involve three key decisions: when, over what geographical scale, and how long to keep schools closed. Our evaluation includes uncertainty and sensitivity analyses, as well as model output uncertainties arising fr...
Source: Epidemics - Category: Epidemiology Source Type: research
Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influenza...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The objective of this preclinical study was to assess the protective immunity induced by immunization with group 1 hemagglutinin-specific influenza virus vaccines based on chimeric hemagglutinins (cHAs) in a ferret model of influenza. The experimental designs and immunization strategies are summarized in Figure 1. Since most human adults have a primed repertoire of B cells with specificity to the HA stalk domain (19, 30), we included an influenza B virus expressing cH9/1 (B-cH9/1) to mimic pre-existing HA stalk immunity. We then compared the ability of our sequential immunization strategies to boost antibody titers against...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Influenza has been impacting public health on a global scale since the beginning of recorded history. Influenza, also known as the “flu,” has numerous organizations committed to public health research, developing vaccines, and educating on best practices to prepare for the upcoming flu season. By gaining an understanding of the flu through history, virology, and how it impacts our society, we can have a better appreciation for the commitment that’s involved with combating the flu. What Is Influenza (and What’s Not)? The eyes of an epidemiologist can twitch for a variety of reasons, one of them being...
Source: JEMS Special Topics - Category: Emergency Medicine Authors: Tags: Exclusive Articles Operations Source Type: news
Abstract In-host mutation of a cross-species infectious disease to a form that is transmissible between humans has resulted with devastating global pandemics in the past. We use simple mathematical models to describe this process with the aim to better understand the emergence of an epidemic resulting from such a mutation and the extent of measures that are needed to control it. The feared outbreak of a human-human transmissible form of avian influenza leading to a global epidemic is the paradigm for this study. We extend the SIR approach to derive a deterministic and a stochastic formulation to describe the evolu...
Source: Theoretical Population Biology - Category: Biology Authors: Tags: Theor Popul Biol Source Type: research
DAVID E. BLOOM is the Clarence James Gamble Professor of Economics and Demography, DANIEL CADARETTE is a research assistant, and JP SEVILLA is a research associate, all at Harvard University’s T.H. Chan School of Public Health.By David E. Bloom, Daniel Cadarette and JP SevillaWASHINGTON DC, Jul 3 2018 (IPS)Infectious diseases and associated mortality have abated, but they remain a significant threat throughout the world.We continue to fight both old pathogens, such as the plague, that have troubled humanity for millennia and new pathogens, such as human immunodeficiency virus (HIV), that have mutated or spilled over ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Active Citizens Development & Aid Economy & Trade Global Headlines Health TerraViva United Nations Source Type: news
Abstract To determine the cross-immunity between influenza strains, we design a novel statistical method, which uses a theoretical model and clinical data on attack rates and vaccine efficacy among school children for two seasons after the 1968 A/H3N2 influenza pandemic. This model incorporates the distribution of susceptibility and the dependence of cross-immunity on the antigenic distance of drifted strains. We find that the cross-immunity between an influenza strain and the mutant that causes the next epidemic is 88%. Our method also gives estimates of the vaccine protection against the vaccinating strain, and ...
Source: Bulletin of Mathematical Biology - Category: Bioinformatics Authors: Tags: Bull Math Biol Source Type: research
This study estimated mortality burden in Beijing associated with seasonal influenza from 2007‐2013 and the 2009 H1N1 pandemic. MethodsWe estimated influenza‐associated excess mortality by fitting a negative binomial model using weekly mortality data as the outcome of interest with the percent of influenza positive samples by type/subtype as predictor variables. ResultsFrom 2007 to 2013, an average of 2,375 (CI 1,002‐8,688) deaths was attributed to influenza per season, accounting for 3% of all deaths. Overall, 81% of the deaths attributed to influenza occurred in adults aged ≥65 years, and the influenza‐associat...
Source: Influenza and Other Respiratory Viruses - Category: Virology Authors: Tags: Review Article Source Type: research
This report summarizes new viral and epidemiologic features identified during the fifth epidemic of Asian H7N9 in China and summarizes ongoing measures to enhance pandemic preparedness. Infections in humans and poultry were reported from most areas of China, including provinces bordering other countries, indicating extensive, ongoing geographic spread. The risk to the general public is very low and most human infections were, and continue to be, associated with poultry exposure, especially at live bird markets in mainland China. Throughout the first four epidemics of Asian H7N9 infections, only low pathogenic avian influen...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
World Health Organization. 06/2017 This introductory level course provides the information and tools needed to better manage disease outbreaks and health emergencies. Materials have been originally designed for World Health Organization African region purposes and have references to Africa more than other continents. Topics include Pandemic Influenza Preparedness Planning; Operationalizing Emergency Response; Global Vaccine Stockpile; and Laboratory Networks to Support Outbreak Surveillance and Response. (Video or Multimedia) Site requires free registration.
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Authors: Source Type: news
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