Hormonal control of metabolism: regulation of plasma glucose

Abstract: The control of plasma glucose needs to be tightly monitored because hyperglycaemia and hypoglycaemia can lead to severe clinical problems, including death. In this article the major mechanism for the transport of glucose into and out of the blood and how that mechanism is used to monitor the circulating concentrations of glucose are discussed. A number of hormones regulate glucose in response to changes in plasma concentrations. Insulin promotes the removal of glucose and its conversion to glycogen. Glucagon, in response to falling glucose concentrations, increases the breakdown of glycogen and the release of glucose from the liver. There are many other hormones that play a part in assisting the functions of insulin and glucagon. Failures in the appropriate production of such hormones may lead to the unregulated changes in plasma glucose and subsequent health problems.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Authors: Tags: Physiology Source Type: research

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The SCOTUS really let me down. They refused to hear the case of Remington whose AR15 was used in the Sandy Hook Massacre. This means the lawsuits can now proceed against Remington. While I deplore mass shootings and the killer the manufacturer of the AR15 should not be held liable. Supreme Court refuses to hear Remington's appeal in lawsuit from Sandy Hook victims The Supreme Court has refused to listen to the appeal of gunmaker Remington in the 2014 lawsuit brought forward by a survivor and families of victims of the 2012 Sandy Hook m...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Anesthesiology Source Type: forums
ConclusionAlthough CISB significantly improved postoperative pain control and early (in the first 6  weeks) functional outcomes following arthroscopic rotator cuff repair, there was no significant difference between the CISB group and CISB + GA group at 6 months.Level of evidenceLevel II, Randomized Controlled Trial, Treatment Study.
Source: European Journal of Orthopaedic Surgery and Traumatology - Category: Orthopaedics Source Type: research
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Source: Johns Hopkins University and Health Systems Archive - Category: Nursing Source Type: news
Publication date: Available online 12 November 2019Source: Wound MedicineAuthor(s): Tanay Bihani, Abhishek Bura, Nilesh MhaskeAbstractWound healing is a general repair response or process of the body immediately after the disruption of the skin integrity. However wound healing is a complex process in which body repairs itself. The aim of this research is to study the wound healing activity of ethanolic extract of Plumeria obtusa leaves and to study the efficacy of formulated 2.5%, 5% and 10% Plumeria obtusa sprays in in-vivo wound healing models. The spray was prepared in three formulations F1, F2 and F3 containing 2.5% (5...
Source: Wound Medicine - Category: General Medicine Source Type: research
This study compares the postoperative pain and opioid use in patients managed for surgery with general anesthesia (GA) with patients who were given combined epidural and general anesthesia (E/GA) with continuing postoperative epidural analgesia. Methods All patients who underwent penile inversion vaginoplasty between May of 2016 and May of 2018 under the care of single surgeon were identified retrospectively, 18 patients of which met the inclusion criteria. A retrospective chart review was conducted. Outcome measures were postoperative pain using visual analog scale, type and dosage of postoperatively administered intra...
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Reconstructive Surgery Source Type: research
Conclusions Continuous or intermittent wound infusion is safe and effective in reducing pain scores and opioid consumption in plastic surgery. Though the overall pain-lowering effect appears to be modest, ease of catheter insertion and patient satisfaction make this technique an alluring alternative to more validated approaches such as neuraxial or peripheral nerve blocks.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Review Paper Source Type: research
In conclusion, the diagnosis of hypoperfusion/microcirculatory abnormalities in peripheral non-vital organs was associated with increased mortality. However, additional studies must be undertaken to verify if this association can be considered a marker of the gravity or a trigger factor for organ failure in sepsis.ResumoEmbora evidências crescentes apoiem a monitorização da perfusão periférica em pacientes sépticos, nenhuma revisão sistemática foi realizada para explorar a força da associação entre a má perfusão avaliada na microcircu...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 11 November 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Başak Altiparmak, Melike Korkmaz Toker, Ali İhsan Uysal, Yağmur Kuşçu, Semra Gümüş DemirbilekAbstractBackground and objectivesThe primary aim of this study is to assess the effect of US-ESP on postoperative opioid consumption after laparoscopic cholecystectomy. The secondary aims are to assess the effects of ESP block on intraoperative fentanyl need and postoperative pain scores.MethodsPatients between 18–70 years old, ASA I-II were included in the study and randomly allocat...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 14 October 2019Source: Brazilian Journal of Anesthesiology (English Edition)Author(s): Gian Luigi Gonnella, Pietro Paolo Giuri, Salvatore De Martino, Luciano Frassanito, Gaetano Draisci
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Publication date: Available online 11 November 2019Source: Fuß &SprunggelenkAuthor(s): N. Maffulli, R. AicaleAbstractIn the past three decades, the incidence of overuse tendinopathy has risen. Tendinopathy affects also middle-aged overweight patients with no history of increased physical activity. Tendinopathy is the result of a chronic failure of healing response. Several conservative therapeutic options have been proposed.The management of tendinopathy is primarily conservative, and many patients respond to such measures. Eccentric exercises and shock wave therapy provide promising excellent clinical results. H...
Source: Fuss and Sprunggelenk - Category: Podiatry Source Type: research
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