Broadly protective human antibodies that target the active site of influenza virus neuraminidase

We describe three human monoclonal antibodies isolated from an H3N2-infected donor that bind with exceptional breadth to multiple different influenza A and B virus neuraminidases. These antibodies neutralize the virus, mediate effector functions, are broadly protective in vivo, and inhibit neuraminidase activity by directly binding to the active site. Structural and functional characterization of these antibodies will inform the development of neuraminidase-based universal vaccines against influenza virus.

Source: ScienceNOW - October 23, 2019 Category: Science Authors: Stadlbauer, D., Zhu, X., McMahon, M., Turner, J. S., Wohlbold, T. J., Schmitz, A. J., Strohmeier, S., Yu, W., Nachbagauer, R., Mudd, P. A., Wilson, I. A., Ellebedy, A. H., Krammer, F. Tags: Immunology, Medicine, Diseases reports Source Type: news