Combined ischemic preconditioning and resveratrol improves blood-brain barrier breakdown via Hippo/YAP/TAZ signaling pathway.

The objective of this study was to survey the treatment function of the activation of the Hippo/YAP signaling pathway by combined ischemic preconditioning (IPC) and resveratrol (RES) before brain ischemia/reperfusion improves blood-brain barrier (BBB) disruption in rats. Sprague-Dawley (SD) rats were pretreated with 20 mg/kg RES and IPC and then subjected to 2 h of ischemia and 22 h of reperfusion. The brain tissues were collected; the cerebral infarct volume was determined; the Evans blue (EB) level, the brain water content (BWC) and apoptosis were assessed; and the expressions of YAP and TAZ were investigated in cerebral tissues. Both IPC and RES preconditioning reduced the cerebral infarct size, improved BBB permeability, lessened apoptosis, and upregulated expressions of YAP and TAZ compared to the ischemia/reperfusion (I/R) group, while combined IPC and RES significantly enhanced this action. PMID: 31642795 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research