EMA Panel Gives Thumbs-up to Fenofibrate/Simvastatin ComboEMA Panel Gives Thumbs-up to Fenofibrate/Simvastatin Combo

The drug, known as Cholib, received a "positive opinion" from CHMP for two doses of the fenofibrate/simvastatin combination. A positive opinion is a prerequisite to approval by the European Commission, which has 67 days from the date of the opinion to grant approval. International Approvals
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Alert Source Type: news

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Condition:   Dilated Cardiomyopathy Intervention:   Drug: Simvastatin Sponsor:   National Taiwan University Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The benefits of statins outweigh the harms, the report asserts, which is likely to renew calls for the release of patient-level data from industry-sponsored statin trials for independent scrutiny.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news
Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.Resumo Fundamentos: Crian ças com hipercolesterolemia familiar podem desenvolver dano endotelial precoce, aumentando o risco de desenvolver doenças cardiovasculares. As estatinas tiveram sua eficácia em diminuir níveis de colesterol LDL e eventos cardiovasculares em adultos comprovada. O efeito das estatinas na populaçã o pediátrica não está claramente demonstrado. Objet...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Conclusion: Statin treatment is efficient in lowering lipids in children with FH. There is need of large, long-term and randomized controlled trials to establish the long-term safety of statins.Resumo Fundamentos: Crian ças com hipercolesterolemia familiar podem desenvolver dano endotelial precoce, aumentando o risco de desenvolver doenças cardiovasculares. As estatinas tiveram sua eficácia em diminuir níveis de colesterol LDL e eventos cardiovasculares em adultos comprovada. O efeito das estatinas na populaçã o pediátrica não está claramente demonstrado. Objet...
Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
Updated Date: Dec 12, 2018 EST
Source: DailyMed Drug Label Updates - Category: Drugs & Pharmacology Source Type: alerts
AbstractCoronary heart disease (CHD) is the leading cause of mortality worldwide and high low-density lipoprotein (LDL) cholesterol levels have been shown to be key in the pathogenesis of this condition. Lipid control has therefore been the subject of decades of research and has led to many large and robust randomized controlled trials, as well as the highest grossing drug of all time —Lipitor (atorvastatin). Statin therapy has long been indicated for secondary and more recently primary prevention. However, despite the large-scale use of statins, CHD prevalence remains high, and some patients do not respond to statin...
Source: Cardiology and Therapy - Category: Cardiology Source Type: research
Mammalian HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the cholesterol biosynthetic pathway and the therapeutic target of statins, is post-transcriptionally regulated by sterol-accelerated degradation. Under cholesterol-replete conditions, HMGCR is ubiquitinated and degraded, but the identity of the E3 ubiquitin ligase(s) responsible for mammalian HMGCR turnover remains controversial. Using systematic, unbiased CRISPR/Cas9 genome-wide screens with a sterol-sensitive endogenous HMGCR reporter, we comprehensively map the E3 ligase landscape required for sterol-accelerated HMGCR degradation. We find that RNF145 and ...
Source: eLife - Category: Biomedical Science Tags: Cell Biology Source Type: research
For most people at risk of heart attack and stroke, using statins to lower cholesterol brings more benefits than risks, say the American Heart Association.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Statins Source Type: news
Title: AHA: New Report Emphasizes Safety of StatinsCategory: Health NewsCreated: 12/10/2018 12:00:00 AMLast Editorial Review: 12/11/2018 12:00:00 AM
Source: MedicineNet Cholesterol General - Category: Cardiology Source Type: news
The benefits of statins are clear, and side effects from the cholesterol-fighting drugs are rare, according to a new analysis of decades of scientific research.
Source: WebMD Health - Category: Consumer Health News Source Type: news
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