Human Health Is in the Hands of Bacteria

In the beginning, there were single-cell bacteria. They were the only life on earth for billions of years, then larger cells evolved, then multicellular organisms, and then plants and animals. But the bacteria never went away, and all organisms, including us humans, have had to learn to live with them. Today, the lessons they are teaching us could change the trajectory of human health for generations. When bacteria were first discovered more than three centuries ago, most attention was on the ones we fought, which caused diseases like cholera, typhoid and tuberculosis. Through vaccines and antibiotics, we have made amazing progress in conquering these scourges. Now, through the combined tools of DNA sequencing and computer-based analysis, we have a first approximation of the innumerable other bacteria with which we cooperate daily. Our microbiome is a diverse array of microbes–bacteria, as well as viruses, fungi and protozoa–that are more or less unique within each of us. We now understand that many are inherited, mostly from Mom, and this represents a continuity of life going back millennia. We know that the microbiomes of peoples living in the forests and savannas–who have had few of the benefits of modern medicine–have much more diverse microbiota than those in industrialized countries do. These comparisons strongly suggest that as the world modernized, we lost much of our microbial heritage. And there’s increasing evidence that those changes...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized medicine Source Type: news

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ConclusionsHypothalamic EPO plays a role in the central regulation of muscle and metabolic physiology while its decline contributes to aging and obesity physiology in a manner which is independent of peripheral EPO.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
This study investigated the protein expression profile of STC1 in PCa and benign prostatic hyperplasia (BPH) samples and STC1 signalling during cell proliferation and cell death in vitro using cell lines. We found higher levels of STC1 in PCa when compared to BPH tissue and that STC1 inhibited forskolin stimulation of cAMP in PC-3 cells. A monoclonal antibody against STC1 was effective in reducing cell proliferation, in promoting cell cycle arrest, and in increasing apoptosis in the same cells. Since STC1 acts as a regulator of prostatic tissue signalling, we suggest that this protein is a novel candidate biomarker for p...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 6 December 2019Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Publication date: November–December 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &Reviews, Volume 13, Issue 6Author(s):
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In conclusion, the role of the anesthetist should be to supervise endoscopy activities at every level. PMID: 31808663 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Zhao Z, Chang MY, Frerichs I, Zhang JH, Chang HT, Gow CH, Möller K Abstract BACKGROUND: Since bronchial abnormalities often exhibit spatial non-uniformity which may be not correctly assessed by conventional global lung function measures, regional information may help to characterize the disease progress. We hypothesized that regional air trapping during mechanical ventilation could be characterized by regional end-expiratory flow (EEF) derived from electrical impedance tomography (EIT). METHODS: Twenty-five patients suffering from chronic obstructive pulmonary disease (COPD grade 3 or 4) or severe...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Our weekly DiabetesMine advice column answers a question about BPA exposure and its effect on diabetes.
Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
Publication date: Available online 6 December 2019Source: Trends in Pharmacological SciencesAuthor(s): Lorenzo GalluzziAlthough somatic KRAS mutations are common in human tumors, no inhibitor of mutant KRAS was clinically available until recently. Canon and colleagues describe the ability of a clinically available KRASG12C inhibitor to drive immunogenic cancer cell death, thus constituting a promising combinatorial partner for immune checkpoint blockers.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
This study investigating a multiphenotypic approach, based on the comparative study of a wild type strain of P. aeruginosa, its isogenic OprF mutant. Both P. aeruginosa PAO1 and OprF mutant strains were grown in same condition and cultures were subjected to further analysis by SDS PAGE, pyocyanin production and biofilm formation that was analyse using scanning electron microscopy. Based on biofilm formation essay and pyocyanin production, the study showed that OprF plays a dynamic role in P. aeruginosa virulence. The absence of OprF results in slow growth rate corresponded to elongated lag phase and reduced biofilm product...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 7 December 2019Source: Saudi Pharmaceutical JournalAuthor(s): Khalid A. Alburikan, Hatem A. AbuelizzAbstractBackgroundMiddle East Respiratory Syndrome (MERS) is a respiratory disease caused by a novel coronavirus that was identified in 2012 in Saudi Arabia. It is associated with significant mortality and morbidity. We identified factors associated with the Middle East Respiratory Syndrome-Coronavirus (MERS‐CoV) infection among suspected cases presented with sign and symptoms of upper respiratory infection or exposure to the virus. We also looked at the impact of medication history on vi...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
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