Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with β S Haplotype in Children with Sickle Cell Anemia.

Effect of N(Epsilon)-(carboxymethyl)lysine on Laboratory Parameters and Its Association with β S Haplotype in Children with Sickle Cell Anemia. Dis Markers. 2019;2019:1580485 Authors: Ndidi US, Adanho CSA, Santiago RP, Yahouédéhou SCMA, Santana SS, Mafili VV, Pitanga TN, Fonseca CA, Ferreira JRD, Adorno EV, Lyra IM, Adekile AD, Barbosa CG, Goncalves MS Abstract The present study aimed to investigate the association of N ε -carboxymethyllysine (CML) with laboratory parameters and β S haplotypes in pediatric sickle cell anemia (SCA) patients with or without hydroxyurea (HU) therapy. We included 55 children with SCA (SCAtotal), where 27 were on HU treatment (SCA-HU+) and 28 without HU treatment (SCA-HU-). Laboratory characteristics were determined using electronic methods while CML was measured using competitive ELISA. β S haplotypes were determined by RFLP-PCR. Significant increases in MCV and MCH and significant decreases in leukocytes, eosinophils, basophils, atypical lymphocytes, lymphocytes, and monocytes were found in SCA-HU+ compared to SCA-HU-. SCA-HU+ presented significant reduction in aspartate transaminase and lactate dehydrogenase and increase in creatinine levels compared to SCA-HU-. CML levels were significantly higher in both SCA-HU+ and SCA-HU- compared to the healthy control. In addition, a negative correlation was found between CML and alanine transaminase in SCA-HU+ and SCAtotal (p
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research

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Condition:   Sickle Cell Anemia in Children Interventions:   Dietary Supplement: Acacia Senegal extract;   Dietary Supplement: Pectin Sponsors:   Al-Neelain University;   University of Khartoum Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Urology - Category: Urology & Nephrology Authors: Tags: Grand Rounds Source Type: research
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study was carried out to compare the fetomaternal outcome in patients with SCD with those without SCD. This was a retrospective cohort study done in the Eastern Province of Saudi Arabia in a tertiary care, teaching hospital, by retrieving the data through the code ICD-9 for SCD, the control group was also selected with comparable characteristics. A total of 302 SCD pregnant patients were included for comparison with 600 pregnant women without SCD as control, during the period of Jan 1, 2008 to December 31, 2018. After the data retrieval, percentages of complications were calculated between the study and control groups...
Source: African Journal of Reproductive Health - Category: African Health Tags: Afr J Reprod Health Source Type: research
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Plastic bronchitis is a potentially fatal disorder characterized by the exudation of proteinaceous material and cells in the airways that leads to branching cast formation, which can be expectorated or lead to asphyxiation. Plastic bronchitis can appear as a complication after single-ventricle palliation. Other causes of plastic bronchitis that have been described include cystic fibrosis, sickle-cell anemia, asthma, and lymphangiomatosis. The underlying pathophysiology of plastic bronchitis seems to be abnormal pulmonary lymphatic perfusion, and the preferred treatment is embolization of the abnormal pulmonary lymphatic vessels (1).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research
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Source: Annals of Hematology - Category: Hematology Source Type: research
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