Deep brain stimulation modulates pallidal and subthalamic neural oscillations in Tourette's syndrome

ConclusionThe high beta and gamma oscillations in GPi restored after GPi ‐DBS, but not STN‐DBS. High beta and gamma oscillations may have physiological function in resisting tics in TS. The cortex compensation effect might be interfered by the STN‐DBS due to the influence on the hyper‐direct pathway but not GPi‐DBS.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Publication date: Available online 27 January 2020Source: The Lancet NeurologyAuthor(s): Franziska Hopfner, Günter U Höglinger, Gregor Kuhlenbäumer, Anton Pottegård, Mette Wod, Kaare Christensen, Caroline M Tanner, Günther DeuschlSummaryBackgroundβ-adrenoceptors are widely expressed in different human organs, mediate important body functions and are targeted by medications for various diseases (such as coronary heart disease and heart attack) and many β-adrenoceptor acting drugs are listed on the WHO Model List of Essential Medicines. β-adrenoceptor antagonists are used by billions ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
We present a neurobiologically plausible elaboration of an existing schema-based cognitive model of action selection in which the basal ganglia implements an activation-based selection process that mediates between assumed cortical representations of rule-based schemas. More specifically, the model employs a network of basal ganglia units with computations performed by individual BG nuclei, embedded in a corticothalamic loop that disinhibits schemas according to the received feedback. We provide bridging assumptions for linking the operation of the model with ERP components that describe the error-related negativity (ERN) ...
Source: Neuropsychologia - Category: Neurology Source Type: research
Conditions:   Huntington Disease;   Deep Brain Stimulation Intervention:   Device: Deep brain stimulation Sponsors:   Beijing Municipal Administration of Hospitals;   Medtronic Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Parkinson Disease Interventions:   Other: 11C-UCB-J PET-CT;   Other: 18F-PE2I PET-MR Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting
Source: - Category: Research Source Type: clinical trials
Publication date: Available online 28 January 2020Source: Journal of Obsessive-Compulsive and Related DisordersAuthor(s): Gregory S. Chasson, C. Elizabeth Hamilton, Alexandria M. Luxon, Andrew J. De Leonardis, Sage Bates, Nisha JagannathanAbstractTreatment ambivalence is commonly associated with hoarding disorder (HD), representing a public health challenge. One possible innovative approach to reducing problematic treatment ambivalence leverages virtual reality (VR) technology as a motivational strategy. For this pilot study, 23 adults with HD were immersed in a VR environment depicting rooms in their own homes without exi...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Publication date: Available online 27 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Stanislaw Szlufik, Karolina Duszynska-Lysak, Andrzej Przybyszewski, Ilona Laskowska-Levy, Agnieszka Drzewinska, Justyna Dutkiewicz, Tomasz Mandat, Piotr Habela, Dariusz KoziorowskiAbstractIntroductionSTN-DBS has been claimed to change progression symptoms in animal models of PD, but information is lacking about the possible neuromodulatory role of STN-DBS in humans. The aim of this prospective controlled study was to evaluate the long-term impact of STN-DBS on motor disabilities and cognitive impairment in PD pati...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 27 January 2020Source: Journal of Clinical NeuroscienceAuthor(s): Contreras-Murillo Gerardo, Magdaleno-Madrigal Víctor ManuelAbstractThis review focuses on the studies that have been reviewed to determine the influence of the thalamic reticular nucleus on neuropsychiatric diseases and deep brain stimulation. The literature reviewed to date describes how alterations in the thalamic reticular nucleus affect several functions that regulated brain rhythms and provokes symptoms of many disorders. The observations as the basis for the renewed interest in the thalamic reticular nucleus in...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
PARKINSON'S disease is a progressive nervous system disorder that affects movement. An obvious early sign of the disease is uncontrolled movements. Less obvious signs of the condition can appear when a person sleeps. What are they?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Neuropsychiatric Disease and Treatment - Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research
This study was registered with the Chinese Clinical Trial Registry under ChiCTR-TRC-14004707. Registered on May 27, 2014.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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