Ambient air pollution and in vitro fertilization treatment outcomes

AbstractSTUDY QUESTIONIs air pollution associated with IVF treatment outcomes in the USA?SUMMARY ANSWERWe did not find clear evidence of a meaningful association between reproductive outcomes and average daily concentrations of particulate matter with an aerodynamic diameter ≤2.5 μm (PM2.5) and ozone (O3).WHAT IS KNOWN ALREADYMaternal exposure to air pollution such as PM2.5, nitrogen oxides, carbon monoxide or O3 may increase risks for adverse perinatal outcomes. Findings from the few studies using data from IVF populations to investigate associations between specific pollutants and treatment outcomes are inconclusive.STUDY DESIGN, SIZE AND DURATIONRetrospective cohort study of 253  528 non-cancelled fresh, autologous IVF cycles including 230 243 fresh, autologous IVF cycles with a transfer of ≥1 embryo was performed between 2010 and 2012.PARTICIPANTS/MATERIALS, SETTING, METHODSWe linked 2010 –2012 National ART Surveillance System data for fresh, autologous IVF cycles with the ambient air pollution data generated using a Bayesian fusion model available through the Centers for Disease Control and Prevention’s Environmental Public Health Tracking Network. We calculated county-level ave rage daily PM2.5 and O3 concentrations for three time periods: cycle start to oocyte retrieval (T1), oocyte retrieval to embryo transfer (T2) and embryo transfer +14  days (T3). Multivariable predicted marginal proportions from logistic and log-linear regression models were used to...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research