Evidence that biopsying, fragmentation and auto-transplantation of ovarian tissue should be abandoned as a treatment of diminished ovarian reserve

In the article by Lunding et al. (2019) ( ‘Biopsying, fragmentation and autotransplantation of fresh ovarian cortical tissue in infertile women with diminished ovarian reserve’) published in this journal, we have evidence that suggests this procedure should be abandoned. Previous reports have proposed that dormant follicles could be act ivated in women with premature ovarian insufficiency through biopsy, fragmentation and auto-transplantation of ovarian tissue, as evidenced by resumption of menses (Zhai et al., 2016) or ovarian response to controlled ovarian stimulation (Suzuki et al., 2015). The authors sought to provide further evidence of benefit, by exploring the use of this procedure in 20 women with diminished ovarian reserve undergoingin vitro fertilization. The authors theorized that either the biopsy or the fragmentation and auto-transplantation would activate dormant follicles and increase follicular development or oocyte yield from the biopsied ovary and/or auto-transplanted tissue.
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research

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