Association between the number of oocytes retrieved and neonatal outcomes after freeze-all IVF cycles

AbstractStudy questionIs there any association between the number of oocytes retrieved and neonatal outcomes following IVF/ICSI treatment for patients using a freeze-all strategy?Summary answerThere was no increased risk of adverse neonatal outcomes in cycles with high number of oocytes retrieved ( ≥ 16) compared to those with 10–15 oocytes retrieved in freeze-all cycles.What is known alreadyRecent studies have found that there is an increased risk of preterm birth (PTB,<37  weeks gestation) and low birth weight (LBW,<2500  g) following IVF in women with a high number (>20) of oocytes retrieved in fresh embryo transfer (ET) cycles. Other studies have found that there is an association between the number of oocytes retrieved and placenta praevia. However, the association between the number of oocytes retrieved and neonatal outcomes when using a freeze-all strategy is unknown.Study design, size, durationThis retrospective cohort study included 14  170 women with singleton deliveries achieved by a freeze-all strategy performed between November 2006 and December 2017 in China. Only the first delivery from one episode of ovarian stimulation was included.Participants/materials, setting, methodsOnly cycles using a freeze-all strategy performed during the study period and resulting in singleton live births were included. Patients were categorized into five groups according to the number of oocytes retrieved: 1 –3, 4–9, 10–15, 16–20 or>20 oocytes. In univar...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research