Durations of Staphylococcus aureus bacteremia according to different phenotypes and a new concept of persistent bacteremia: a prospective cohort study.

Durations of Staphylococcus aureus bacteremia according to different phenotypes and a new concept of persistent bacteremia: a prospective cohort study. Antimicrob Agents Chemother. 2019 Oct 21;: Authors: Kang CK, Song KH, Kim SE, Kim ES, Park WB, Park KH, Chun SH, Lee S, Cho CR, Kang SJ, Oh MD, Kim YS, Lee SH, Kwak YG, Jang HC, Kim CJ, Kim YK, Bang JH, Kiem S, Kwon KT, Jung Y, Kang YM, Jung SI, Kim HB, Korea INfectious Diseases (KIND) study group Abstract The purpose of this study was to describe and compare the duration of Staphylococcus aureus bacteremia (SAB) according to methicillin resistance and primary foci of infection. We also aimed to newly define persistent SAB considering these results. Non-duplicated episodes of SAB in patients aged ≥15 years from 14 hospitals between January 2009 and February 2018 in Korea were analyzed. The duration of SAB was defined as the number of days from the administration of a susceptible antibiotic after the onset of SAB to the last day of positive blood culture for S. aureus SAB durations were described and compared based on methicillin resistance and the primary foci of infection. Cases in the top quartile for the duration of bacteremia under the respective clinical context were classified as newly defined persistent SAB, and its association with in-hospital mortality was evaluated. A total of 1917 cases were analyzed. The duration of SAB was longer in methicillin-resistant SAB (MRSAB, n=9...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research