Prevalence of community-acquired bloodstream infections among hospitalized patients in Africa and Asia: a systematic review and meta-analysis.

Prevalence of community-acquired bloodstream infections among hospitalized patients in Africa and Asia: a systematic review and meta-analysis. Antimicrob Agents Chemother. 2019 Oct 21;: Authors: Marchello CS, Dale AP, Pisharody S, Rubach MP, Crump JA Abstract Community-acquired bloodstream infections (CA-BSI) are major causes of severe febrile illness and death worldwide. In light of new data and the growing problem of antimicrobial resistance (AMR) among pathogens causing BSI, we undertook a systematic review of hospital-based studies of CA-BSI among patients hospitalized with fever. Without restriction to language or country, we searched PubMed, Web of Science, and Scopus for prospective hospital-based studies of community-acquired, culture-confirmed BSI among febrile inpatients. We determined by study the prevalence of BSI among participants, pathogens responsible for BSI, and antimicrobial susceptibility patterns of pathogens causing BSI in place and time. Thirty-four (77.3%) of 44 eligible studies recruited 29,022 participants in Africa and Asia combined. Among participants in these two regions, the median (range) prevalence of BSI was 12.5% (2.0-48.4%) and of 3,220 pathogens isolated, 1,119 (34.8%) were Salmonella enterica, 425 (13.2%) Streptococcus pneumoniae, and 282 (8.8%) Escherichia coli Antimicrobial susceptibility testing was reported in 16 (36.4%) studies. When comparing isolates prior to 2008 to the period 2008 through...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research