Modeling tissue-selective cavitation damage.

In this study, numerical simulations are used to calculate stress, strain, and strain rate fields produced by bubble oscillation under histotripsy forcing in a variety of tissues with literature-sourced viscoelastic and acoustic properties. Strain field calculations are then used to predict a theoretical damage radius using tissue ultimate strain data. Simulation results support the hypothesis that differential tissue responses could be used to design tissue--selective treatments. Results agree with studies correlating tissue ultimate fractional strain with resistance to histotripsy ablation and are also consistent with experiments demonstrating smaller lesion size under exposure to higher frequency waveforms. Methods presented in this study provide an approach for modeling tissue--selective cavitation damage in general. PMID: 31639778 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31639778?dopt=Abstract

Source: Physics in Medicine and Biology - October 21, 2019 Category: Physics Authors: Mancia L, Vlaisavljevich E, Yousefi N, Rodriguez M, Ziemlewicz TJ, Lee FT, Henann D, Franck C, Xu Z, Johnsen E Tags: Phys Med Biol Source Type: research