A Tiered Strategy for Investigating Status Epilepticus

Publication date: Available online 22 October 2019Source: SeizureAuthor(s): Donald P. Craig, Tejal N. Mitchell, Rhys H. ThomasAbstractIn status epilepticus the imperative to start anti-seizure therapy, initially subjugates the need to investigate the cause. Once treatment is initiated this balance shifts in favour of identifying: the causes and consequences of the seizure; the factors that predetermined the occurrence of status epilepticus; and finally the prognosis of this acute episode. Just as there are multiple causes of seizures and epilepsy, there are a vast number of causes of status epilepticus. We discuss the more common and the more important to identify as they may dictate a change in therapy or a certain prognosis.Acknowledging that the burden of epilepsy and status epilepticus is preferentially felt in developing nations, we have tried to rationalise the investigation of status epilepticus. Basic laboratory studies are necessary in all patients with status epilepticus as systemic complications can occur early and can involve every organ system. Aetiology is important, however the morbidity from treatment does not discriminate when treatment resistant status epilepticus is due to dissociative seizures.Seven percent of epilepsy hospitalisations are for status epilepticus and epilepsy is a prior diagnosis half the time; awareness of prior history is invaluable. EEG is critical for diagnosis in the anaesthetised patient or those in non-convulsive status epilepticus. ...
Source: Seizure - Category: Neurology Source Type: research

Related Links:

We present a case report of a female with severe generalized gingival fibromatosis and hypertrichosis which was treated by conventional gingivectomies under local anesthesia. Postoperative healing was uneventful with a marked improvement in patient's appearance and oral hygiene.
Source: Journal of Indian Society of Periodontology - Category: Dentistry Authors: Source Type: research
EPILEPSY IS a generic term referring to a condition characterized by recurrent unprovoked seizures.1 The management of epilepsy in the perioperative period is closely related to the management of antiepileptic drugs (AEDs). Of the commonly used AEDs, the perioperative management of phenytoin presents a challenge because of its unique pharmacokinetic properties. Phenytoin binds to neuronal voltage-gated sodium channels while in their inactive state to increase their duration of inactivity. This translates into a reduction in the frequency with which neurons can propagate action potentials.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Case Report Source Type: research
This article discusses the peri-operative considerations of multiple anti-epileptic medications, recent advances in anesthetic management, and important post-operative concerns.
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
In this report is described a case of West Syndrome patient affected by multiple caries, gingival enlargement, dental eruption abnormalities, high-arched palate and Molar Incisors Hypomineralization, treated at the dental clinic of University of Bari "Aldo Moro". DISCUSSION: West patients present with multiple oral abnormalities, including altered eruption timing, teeth agenesis, teeth shape and position abnormalities, plaque and calculus accumulation, malocclusions and bad oral habits (mouth breathing, nails biting). West Syndrome patients' oral hygiene is generally bad due to their motor difficulty and to ...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Publication date: Available online 8 November 2019Source: Epilepsy &BehaviorAuthor(s): Sara HockerAbstractThe epidemiology of status epilepticus (SE) and predictors of outcome in particular have been well described with consistent findings around the world. Understanding of the actual causes of death in patients hospitalized with SE is limited. The following is a summary of published information about causes of death in patients hospitalized with SE and a reconciling of conflicting studies examining the influence of continuous intravenous anesthetic drugs on the mortality of SE. A recently published paper was presented...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Status epilepticus (SE) represents a neurological emergency that requires urgent treatment and rapid escalation of care if symptoms do not subside within a short time from onset [1]. The progression to Refractory Status Epilepticus (RSE) is reported in 40% of SE cases (Rossetti and Lowenstein. 2011), often requiring intravenous anaesthetic treatment (IVAT) and critical care admission [2]. RSE, though, still associates with substantial morbidity and mortality [3 –5].
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Abstract The epidemiology of status epilepticus (SE) and predictors of outcome in particular have been well described with consistent findings around the world. Understanding of the actual causes of death in patients hospitalized with SE is limited. The following is a summary of published information about causes of death in patients hospitalized with SE and a reconciling of conflicting studies examining the influence of continuous intravenous anesthetic drugs on the mortality of SE. A recently published paper was presented at the Colloquium and is summarized here, along with new data addressing an audience questi...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
This article presents a super obese patient (BMI 57 kg/m2) with drug-refractory epilepsy and obstructive sleep apnea who underwent left anterior temporal lobectomy through awake craniotomy to preserve language and memory, using warmed humidified high flow nasal cannula (HFNC) oxygen therapy. Awake craniotomy was facilitated by the use of HFNC, which proved essential to prevent airway collapse by creating continuous positive airway pressure through high flow and facilitated intraoperative neurologic language and memory testing while maintaining adequate oxygenation. PMID: 31686115 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - Category: Anesthesiology Authors: Tags: Anaesthesist Source Type: research
This article is part of the Special Issue “Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures”.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This article is part of the Special Issue "Proceedings of the 7th London-Innsbruck Colloquium on Status Epilepticus and Acute Seizures". PMID: 31676239 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
More News: Anesthesia | Anesthesiology | Epilepsy | Laboratory Medicine | Neurology | Study