Targeting tauopathy with engineered tau-degrading intrabodies

The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic app...

Source: Molecular Neurodegeneration - October 22, 2019 Category: Neurology Authors: Gilbert Gallardo, Connie H. Wong, Sara M. Ricardez, Carolyn N. Mann, Kent H. Lin, Cheryl E. G. Leyns, Hong Jiang and David M. Holtzman Tags: Research article Source Type: research