Development of conjugate-by-conjugate structured nanoparticles for oral delivery of docetaxel

This study created newly modified structures of HPMC and chitosan, altering their physicochemical properties that could then retard drug release. The nanoparticles were cytotoxic towards MDA-MB-231 breast cancer cells when docetaxel was loaded in the nanoparticles, particularly the nanoparticles produced in the second approach, demonstrating their ability to kill cancerous cells and their potential for further applications in cancer therapy. Additionally, when Caco-2 cells were used as an absorption model in a transport study, the nanoparticles in the second approach showed their capacity to increase drug permeability across the monolayers of Caco-2 cells compared to the free-drug solution. This study also illustrated the enhanced uptake of the nanoparticles by the Caco-2 cells, implying enhanced absorption through the intestine. Therefore, these oral nanoparticles can be considered for delivery systems of agents that are sensitive to the gastrointestinal tract so that they can be transported across the epithelial cells to the bloodstream to deliver the loading cargo at an optimal concentration.
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research

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This article presents a unique 3D biocompatible Aluminum-based quantum structure (QS) for in vitro cancer detection using Surface Enhanced Raman Scattering (SERS). The Al-based QSs fabricated using ultrashort pulsed laser are of two distinct surface characters, wrinkled and smooth spherical. The limit of detection for chemical sensing of Crystal Violet and Rhodamine 6G by the Al-QS was driven up to single molecule sensing (femtomolar concentration). Biological sensing of cysteine, a disease biomarker and carcinoembryonic antigen (CEA), a cancer biomarker was also tested by the Al-QS. The ability of in vitro cell detection ...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
This study suggests that these bioformulations could be essential towards sustainable agricultural science deprived of harming the ecosystem. The synthesized bioformulations have enormous potential to be commercially explored for agriculture use.Graphical abstract
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
In this study, four different weight% of Punica granatum fruit peel extract were used as green stabilizers to synthesize IONPs followed by a series of characterization experiments and in vitro anticancer evaluation. Results revealed that all synthesized IONPs have high degree of crystallinity and purity. The optimum saturation magnetization, and hydrodynamic size were found to be ∼69 emu.g−1, and 26.52 nm, respectively. Morphological studies demonstrated that adding peel extract decreased size of NPs with the average particle size below 11 nm. Cytotoxicity assay showed that the IONPs were not react...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 March 2020Source: Journal of Molecular Structure, Volume 1204Author(s): A.D. Herrera-España, J. Us-Martín, S. Hernández-Ortega, G. Mirón-López, L. Quijano, J.R. Villanueva-Toledo, G.J. Mena-RejónAbstractThe structural modification of natural products has shown to be a remarkable tool in the generation of novel bioactive molecules. Herein, the synthesis, structural analysis and anticancer activity of the novel triterpenoid thiazole 3 is reported. The synthesis was carried out through the bromination of ochraceolide A (1) and the subsequent heterocyclic condensat...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: Available online 14 December 2019Source: Thermochimica ActaAuthor(s): Vargas H. María Ángeles, Belkis Sulbarán-Rangel, Humberto Vázquez-TorresAbstractThe non-isothermal curing kinetics of furfuryl alcohol (FA) with p-toluenesulfonic acid (p-TSA-2 wt%), two graphene oxides with different content of oxygen and a high thermally reduced graphene oxide at different concentrations (2, 4, 6 wt%) were studied by DSC using four heating rates (5, 7.5, 10 and 15 K min-1). The graphene particles were characterized by infrared spectroscopy, Raman spectroscopy, 13C solid...
Source: Thermochimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 14 December 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Xinxin Shi, Yalei Hu, Hong-Min Meng, Jie Yang, Lingbo Qu, Xiao-Bing Zhang, Zhaohui LiAbstractIntracellular polarity has a large impact on the activity of a series of biomolecules or maintain the function of particular domains. Therefore, monitoring the changing of intracellular polarity can great improve the understanding its functions in living cell level. Herein, by employing p-phenylenediamine as precursor, we prepared a red emissive carbon dots based nanoprobe for real-time sensing polarity in living cells. With the i...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: Available online 15 December 2019Source: European Polymer JournalAuthor(s): Nana Zhang, Shoujuan Wang, Magdi E. Gibril, Fangong KongAbstractApplication of the lignin-based monomer in polymers synthesis will reducing the use of petrochemical-based monomers, enhance the polymer/copolymers properties, and disposing lignin in a profitable way. Accordingly, in this work, the lignin-vinyl acetate monomer (LVAc) and its copolymers were synthesized successfully. To obtain the LVAc, firstly, lignin was activated with the amine using diethylenetriamine (DETA) and then followed by the grafting with chlorovinyl aceta...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 14 December 2019Source: Chemical Engineering and Processing - Process IntensificationAuthor(s): Lívia N. Ribeiro, Aline C.S. Fonseca, Emerson F.M. da Silva, Evelle D.C. Oliveira, André T.S. Ribeiro, Laisse C.A. Maranhão, Jose G.A. Pacheco, Giovanna Machado, Luciano C. AlmeidaABSTRACTA batch-process with a dispersed solid photocatalyst requires a large reactor and unit process for catalyst recovery, increasing the treatment cost. Structured-supported photocatalysts enable the use of continuous compact reactors that are photoactivated by solar energy and promote process...
Source: Chemical Engineering and Processing: Process Intensification - Category: Chemistry Source Type: research
This study advances the application of this oxidation system.Graphical abstract
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
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