The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation.

The Golgi Apparatus: Panel Point of Cytosolic Ca2+ Regulation.
Neurosignals. 2013 Jun 22;
Authors: Li LH, Tian XR, Jiang Z, Zeng LW, He WF, Hu ZP
Abstract
The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca(2+) store because different Ca(2+) regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca(2+)-ATPase and secretory pathway Ca(2+)-ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca(2+) release and uptake in the GA have now been established. Here, based on careful backward looking on compartments and patterns in GA Ca(2+) regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca(2+) adjustment model, in which GA acts as part of the panel point.
PMID: 23796968 [PubMed - as supplied by publisher]

Source: Neuro-Signals - June 22, 2013 Category: Neurology Authors: Li LH, Tian XR, Jiang Z, Zeng LW, He WF, Hu ZP Tags: Neurosignals Source Type: research