Kentucky Communities and Researchers Engaging to Halt the Opioid Epidemic (CARE2HOPE)
Conditions: Substance Use; HIV Infections; HCV Infection; Sexually Transmitted Infections (Not HIV or Hepatitis); Overdose, Drug; Opioid Use Interventions: Behavioral: Re-entry Health Linkage; Behavioral: Overdose Education Sponsors: University of Kentucky; National Institute on Drug Abuse (NIDA); Substance Abuse and Mental Health Services Administration (SAMHSA); Emory University; Temple University Not yet recruiting
Overexpression of AKR1B10 correlated with tumorigenesis of many human malignancies; however, the prognostic value of AKR1B10 expression in patients with hepatocellular carcinoma (HCC) still remains controversial. In this analysis, AKR1B10 expression in HCC tumors were evaluated in GEO, TCGA and Oncomine databases, and a survival analysis of AKR1B10 based on TCGA profile was performed. We found that AKR1B10 was significantly overexpressed in tumors compared with nontumors in 7 GEO series (GSE14520, GSE25097, GSE33006, GSE45436, GSE55092, GSE60502, GSE77314) and TCGA profile (all P
In conclusion, circulating microRNAs, particularly the miR-125b, may serve as promising biomarkers for the early diagnosis of HBV-related HCC. However, larger and more rigorous studies are needed to confirm our conclusions.