Sirtuin 1 alleviates endoplasmic reticulum stress-mediated apoptosis of intestinal epithelial cells in ulcerative colitis.

CONCLUSION: SIRT1 activation reduces apoptosis of IECs via the suppression of endoplasmic reticulum stress-mediated apoptosis-associated molecules CHOP and caspase-12. SIRT1 activation may be a potential therapeutic strategy for UC.
PMID: 31636473 [PubMed - in process]

Source: World Journal of Gastroenterology : WJG - October 13, 2019 Category: Gastroenterology Authors: Ren MT, Gu ML, Zhou XX, Yu MS, Pan HH, Ji F, Ding CY Tags: World J Gastroenterol Source Type: research