Mania induced by tramadol-venlafaxine combination.

Mania induced by tramadol-venlafaxine combination. J Opioid Manag. 2019 Jul/Aug;15(4):342-344 Authors: Hefzi N, Grekin J, Ahmed A Abstract A 49-year-old male with major depressive disorder well-managed with venlafaxine [serotonin and norepinephrine reuptake inhibitor (SNRI)] and no history of manic episodes developed his first manic episode following use of tramadol. Tramadol-induced mania has been described with selective serotonin reuptake inhibitors but not SNRIs. In addition, mania is not listed as a potential clinical side effect-further illustrating this relative rarity. Due to tramadol's SNRI activity, there is definitive risk for mood lability in individuals managed with tramadol and other serotonergic medications as seen in this patient. The authors findings suggest the need for greater risk consideration when prescribing tramadol with other related agents such as venlafaxine. PMID: 31637686 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31637686?dopt=Abstract

Source: Journal of Opioid Management - October 23, 2019 Category: Addiction Tags: J Opioid Manag Source Type: research