Nuclear miR-320 Mediates Diabetes-Induced Cardiac Dysfunction by Activating Transcription of Fatty Acid Metabolic Genes to Cause Lipotoxicity in the Heart.

Conclusions: These findings uncover a novel mechanism for diabetes-triggered cardiac dysfunction, provide an endogenous case for saRNA that has been demonstrated so far only with synthetic RNAs in transfected cells, and suggest a potential strategy to develop a miRNA-based therapy to treat diabetes-associated cardiovascular complications.
PMID: 31638474 [PubMed - as supplied by publisher]

Source: Circulation Research - October 21, 2019 Category: Cardiology Authors: Li H, Fan J, Zhao Y, Zhang X, Dai B, Zhan J, Yin Z, Nie X, Fu XD, Chen C, Wang DW Tags: Circ Res Source Type: research