Brown adipose cross talk in tissue plasticity and human metabolism.

Brown adipose cross talk in tissue plasticity and human metabolism. Endocr Rev. 2019 Oct 22;: Authors: Scheele C, Wolfrum C Abstract Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increase metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclimation and include secretion of factors, known as batokines, which target several different cell types within the BAT, and promote adipogenesis, angiogenesis, immune cell interactions and neurite outgrowth. All these processes seem to act in concert to promote an adapted BAT. Recent studies have also provided exciting data on whole body metabolic regulation with a broad spectrum of mechanisms involving BAT cross talk with liver, skeletal muscle and gut as well as the central nervous system. These wide-spread interactions might reflect the property of BAT of switching between an active thermogenic state where energy is highly consumed and drained from the circulation, and the passive thermoneutral state, where energy consumption is turned off. PMID: 31638161 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research