Peroxisome Proliferator‐Activated Receptors α and γ are Linked with Alcohol Consumption in Mice and Withdrawal and Dependence in Humans

ConclusionsWe provide convergent evidence using both mouse and human data for specific PPARs in alcohol action. Reduced EtOH intake in mice and the genetic association between AD or withdrawal in humans highlight the potential for repurposing FDA‐approved PPARα or PPARγ agonists for the treatment of AD.

Source: Alcoholism: Clinical and Experimental Research - December 16, 2014 Category: Addiction Authors: Yuri A. Blednov, Jillian M. Benavidez, Mendy Black, Laura B. Ferguson, Grant L. Schoenhard, Alison M. Goate, Howard J. Edenberg, Leah Wetherill, Victor Hesselbrock, Tatiana Foroud, R. Adron Harris Tags: Original Article Source Type: research