Bacterial outer membrane vesicles engineered with lipidated antigens as a platform for Staphylococcus aureus vaccine [Microbiology]

Bacterial outer membrane vesicles (OMVs) represent an interesting vaccine platform for their built-in adjuvanticity and simplicity of production process. Moreover, OMVs can be decorated with foreign antigens using different synthetic biology approaches. However, the optimal OMV engineering strategy, which should guarantee the OMV compartmentalization of most heterologous antigens in quantities...

Source: Proceedings of the National Academy of Sciences - October 21, 2019 Category: Science Authors: Carmela Irene, Laura Fantappie, Elena Caproni, Francesca Zerbini, Andrea Anesi, Michele Tomasi, Ilaria Zanella, Simone Stupia, Stefano Prete, Silvia Valensin, Enrico Konig, Luca Frattini, Assunta Gagliardi, Samine J. Isaac, Alberto Grandi, Graziano Guella Tags: PNAS Plus Source Type: research