A cytonaut's guide to protein trafficking in Giardia lamblia.

A cytonaut's guide to protein trafficking in Giardia lamblia. Adv Parasitol. 2019;106:105-127 Authors: Faso C, Hehl AB Abstract Over the past years, the subcellular organization of the Excavata member Giardia lamblia (syn. duodenalis, intestinalis) has been investigated in considerable detail. There are several reasons for this endeavour which go beyond this parasite's medical importance and are mostly concerned with its reduced subcellular complexity and debated evolutionary status. One may say that simplification has emerged as a paradigm for the evolution of Giardia's subcellular architecture. However, a complete appreciation of the evolutionary and ecological significance of this phenomenon is far from complete. In this chapter, we present and discuss the most recent data on the main trafficking pathways in G. lamblia which include endo- and exo-cytosis, organellar import and function. We provide perspectives on open questions concerning organelle replication and inheritance and include a technical outlook on methods and approaches to genetic manipulations in G. lamblia. A better understanding of G. lamblia subcellular organization at the morphological and molecular level complements any effort aimed at elucidating this parasitic species' evolutionary status and could provide us with the basis for novel strategies to interfere with parasite transmission and/or pathogenesis. PMID: 31630756 [PubMed - in process]
Source: Advances in Parasitology - Category: Parasitology Authors: Tags: Adv Parasitol Source Type: research

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CONCLUSIONS: . Mechanical, thermal shock, and enzymatic pre-treatments are necessary for the rupture of the cystic wall of Giardia spp. making it the highest-yielding bg molecular marker for detecting cyst DNA. Trophozoites do not require pre-treatment to achieve satisfactory results. A reproducible methodology for the extraction of DNA from Giardia spp. from any evolutionary stage is available. PMID: 31800934 [PubMed - in process]
Source: Revista Peruana de Medicina de Experimental y Salud Publica - Category: International Medicine & Public Health Tags: Rev Peru Med Exp Salud Publica Source Type: research
Publication date: Available online 3 December 2019Source: Veterinary ParasitologyAuthor(s): Yoko Nagamori, Mark E. Payton, Emily Looper, Hadley Apple, Eileen M. JohnsonAbstractOwnership of domestic cats in North America has been on the increase; however, there are only a few surveys conducted on the prevalence of parasitism in client-owned cats over years. Our study objective was to evaluate parasite prevalence through statistical analysis of fecal examination results for client-owned cats on samples submitted to the veterinary parasitology diagnostic laboratory of Oklahoma State University over a 12-year period. All resul...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research
Answer:Giardia duodenalis(a.k.a.G. lamblia, G. intestinalis) trophozoites with " falling leaf " or " tumbling " motility. Note that this is quite different than the " spiraling " motility ofChilomastix mesnili and the " jerky " motility ofPentatrichomonas hominis - two other flagellates - both non-pathogns - that may be seen in human stool specimens.As pointed out by Florida Fan, the motility is further enhanced by dark field videography, which makes everything more interesting. Thanks again to Idzi for the very cool videos!Santiago gave us further information on howGiardia...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
This study was conducted to assess the infection rates, genetic identit...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
ConclusionsAll three RDTs forCryptosporidium spp. andGiardia duodenalis evaluated in this study have a moderate sensitivity, but sufficient specificity. The main value of the RDTs is within their rapidness and their usefulness as screening assays in surveys for diarrhoea.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
This study provides baseline information for better understanding the status of parasitic infections in Palestine and compares their epidemiology between the West Bank and Gaza Strip. Appropriate control measures and health education directed to the public about preventive measures should be considered to raise awareness about parasitic infections to lower their incidences and burden in Palestine. PMID: 31769396 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
The aim of this study was to assess potential associations between Giardia duodenalis infection in dogs, as determined by three diagnostic tests, and dog ’s group of origin, fecal consistency, age, sex, neuter sta...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
la SS Abstract Intestinal parasites cause a significant public health problem worldwide due to the associated morbidities, mainly in infected school-aged children (SAC). The strategy of large-scale deworming in SAC to control the transmission of soil-transmitted helminths (STH) has been advocated by the World Health Organization and was recently adopted in Brazil; however, the long-term effects of mass deworming on the larger parasitological profile have been less studied. After a five-year period of school-based large-scale treatment for STH using an annual single dose of albendazole in a community of Sergipe sta...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
Authors: Ma DW, Lee MR, Hong SH, Cho SH, Lee SE Abstract Cryptosporidium parvum and Giardia duodenalis are the main diarrhea-causing parasitic pathogens; however, their prevalence in Korea is unknown. Here, we conducted a survey to determine the prevalence and genotype distribution of these 2 pathogens causing acute diarrhea in 8,571 patients hospitalized in 17 Regional Institute of Health Environment sites in Korea, during 2013-2016. C. parvum and G. duodenalis were detected and genotyped by nested PCR, and the isolate were molecularly characterized by sequencing the glycoprotein 60 (Gp60) and β-giardin genes...
Source: Korean Journal of Parasitology - Category: Parasitology Tags: Korean J Parasitol Source Type: research
Cryptosporidium spp. and Giardia duodenalis are major intestinal pathogens that can cause diarrheal diseases in humans, especially children. Enterocytozoon bieneusi is another parasite which can cause gastrointes...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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