A cytonaut's guide to protein trafficking in Giardia lamblia.

A cytonaut's guide to protein trafficking in Giardia lamblia.
Adv Parasitol. 2019;106:105-127
Authors: Faso C, Hehl AB
Abstract
Over the past years, the subcellular organization of the Excavata member Giardia lamblia (syn. duodenalis, intestinalis) has been investigated in considerable detail. There are several reasons for this endeavour which go beyond this parasite's medical importance and are mostly concerned with its reduced subcellular complexity and debated evolutionary status. One may say that simplification has emerged as a paradigm for the evolution of Giardia's subcellular architecture. However, a complete appreciation of the evolutionary and ecological significance of this phenomenon is far from complete. In this chapter, we present and discuss the most recent data on the main trafficking pathways in G. lamblia which include endo- and exo-cytosis, organellar import and function. We provide perspectives on open questions concerning organelle replication and inheritance and include a technical outlook on methods and approaches to genetic manipulations in G. lamblia. A better understanding of G. lamblia subcellular organization at the morphological and molecular level complements any effort aimed at elucidating this parasitic species' evolutionary status and could provide us with the basis for novel strategies to interfere with parasite transmission and/or pathogenesis.
PMID: 31630756 [PubMed - in process]

Source: Advances in Parasitology - October 23, 2019 Category: Parasitology Authors: Faso C, Hehl AB Tags: Adv Parasitol Source Type: research