Keratinocyte growth factor reduces injury and leads to early recovery from cyclophosphamide bladder injury

Keratinocyte growth factor (KGF) improves outcomes after cyclophosphamide-induced bladder injury. To understand the underlying mechanisms, we subcutaneously administered KGF to mice 24 hours prior to intraperitoneal cyclophosphamide administration, followed by histological assays and immunostaining. In vehicle (PBS)-pretreated mice, non-apoptotic superficial urothelial cell death from two to six hours and apoptosis in intermediate and basal cells from four to 24 hours was observed post cyclophosphamide treatment.

Source: American Journal of Pathology - October 21, 2019 Category: Pathology Authors: Sridhar Tatarao Narla, Daniel Scott Bushnell, Caitlin Marie Schaefer, Mehdi Nouraie, Carlton Matthew Bates Tags: Regular Article Source Type: research