Cytoglobin deficiency potentiates Crb1-mediated retinal degeneration in rd8 mice.

CONCLUSIONS: Cygb is necessary for retinal lamination, maintenance of cell polarity, and photoreceptor survival in rd8 mice. These results are consistent with Cygb as a disease modifying gene in Crb1-related retinopathy. Further studies are necessary to investigate the role of Cygb in the human retina. PMID: 31634437 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31634437?dopt=Abstract

Source: Developmental Biology - October 17, 2019 Category: Biology Authors: Kwon YS, Tham A, Lopez AJ, Edwards S, Woods S, Chen J, Fortunato J, Quiroz A, Javier S, Au I, Clarke M, Humpal D, Lloyd KCK, Thomasy S, Murphy C, Glaser TM, Moshiri A Tags: Dev Biol Source Type: research