Antimicrobial Activity of Ceftolozane-Tazobactam Tested against Contemporary (2015-2017) P. aeruginosa Isolates from a Global Surveillance Program

ConclusionsC-T had potent activity against P. aeruginosa isolated from patients in hospitals in 4 continents. C-T was more active than all comparators, except COL, and maintained activity against MDR and XDR isolates and isolates non-susceptible to all 4 tested BLs. C-T was active against 12/16 COL-NS isolates.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research

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CONCLUSION: Prevalence of antibiotic use was high not only versus other hospitals in the region but globally including Africa, coupled with significant evidence of sub-optimal prescribing. Swift action is needed to improve future prescribing to reduce AMR. One or two areas should initially be targeted for quality improvement including development of local guidelines, documentation of antibiotic indications and/or stop/review dates. PMID: 33034234 [PubMed - as supplied by publisher]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Authors: Rombauts A, Abelenda-Alonso G, Cuervo G, Gudiol C, Carratalà J Abstract INTRODUCTION: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant in severe cases. The intensity of the dysregulated host response varies from patient to patient and has a negative impact on survival and other outcomes. AREAS COVERED: This comprehensive review summarizes the pathophysiological aspects of the inflammatory response in CAP, brie...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Authors: Reissier S, Cattoir V Abstract INTRODUCTION: Streptogramins (pristinamycin and quinupristin-dalfopristin) can be interesting options for the treatment of infections due to Gram-positive cocci, especially multidrug-resistant isolates. AREAS COVERED: This review provides an updated overview on structural and activity characteristics, mechanisms of action and resistance, pharmacokinetic/pharmacodynamic and clinical use of streptogramins. EXPERT OPINION: The streptogramin antibiotics act by inhibition of the bacterial protein synthesis. They are composed of two chemically distinct compounds, namely typ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Authors: Tamai H, Shingaki N, Ida Y, Shimizu R, Maeshima S, Okamura J, Kawashima A, Nakao T, Hara T, Matsutani H, Nishikawa I, Higashi K Abstract BACKGROUND: Although clinical use of sofosbuvir plus ribavirin has been approved for patients infected with genotype 2 hepatitis C virus, patients ≥ 75-years-old have not been included in previous clinical trials. AIM: To evaluate the real-world safety and efficacy of sofosbuvir plus ribavirin for elderly patients (≥ 75-years-old) compared to nonelderly patients, we conducted a post-marketing prospective cohort study. METHODS: We treated 265 patients with ge...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Authors: Yamaya T, Baba T, Hagiwara E, Ikeda S, Niwa T, Kitayama T, Murohashi K, Higa K, Sato Y, Ogura T Abstract Coronavirus disease 2019 (COVID-19) has been recognized as a worldwide pandemic. However, the clinical course of COVID-19 remains poorly characterized. Although some cases of pneumothorax have been reported, they all had pulmonary complications or were managed with mechanical ventilation. We herein report a case of pneumothorax that developed even though the patient had no pulmonary underlying diseases and had never been managed with mechanical ventilation. In the present case, a lung bulla was found on...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Takahashi M, Horio Y, Takihara T, Enokida K, Miyaoka M, Hirabayashi K, Ohshinden K, Hattori S, Takahashi F, Takahashi G, Tanaka J, Takiguchi H, Niimi K, Ito Y, Hayama N, Oguma T, Asano K Abstract A 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 8 October 2020Source: European Journal of RadiologyAuthor(s): Davide Colombi, Marcello Petrini, Gabriele Maffi, Gabriele D. Villani, Flavio C. Bodini, Nicola Morelli, Gianluca Milanese, Mario Silva, Nicola Sverzellati, Emanuele Michieletti
Source: European Journal of Radiology - Category: Radiology Source Type: research
Publication date: Available online 9 October 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Elma L. Leite, Wydemberg J. Araújo, Tatiana R. Vieira, Karoline S. Zenato, Priscylla C. Vasconcelos, Samuel Cibulski, Patricia E.N. Givisiez, Marisa R.I. Cardoso, Celso J.B. Oliveira
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 8 October 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): E.L. Looman, P. van Tienen, D.Y.K. Ng, S. Baig, A. Fait, S. Overballe-Petersen, P.S. Andersen, M. Stegger
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 8 October 2020Source: Journal of Cardiology CasesAuthor(s): Masahiko Nakao, Junji Matsuda, Miho Iwai, Akira Endo, Taishi Yonetsu, Yasuhiro Otomo, Tetsuo Sasano
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
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