Anthrax: Developing Drugs for Prophylaxis of Inhalational Anthrax Guidance for Industry

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Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news

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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Three medical stories that we didn't cover, explained.Medscape
Source: Medscape General Surgery Headlines - Category: Surgery Tags: Internal Medicine Article Source Type: news
AbstractThe most promising means of controlling anthrax, a lethal zoonotic disease during the early infection stages, entail restricting the resilient infectious form, i.e., the spores from proliferating to replicating bacilli in the host. The extractible antigen (EA1), a major S-layer protein present on the vegetative cells and spores ofBacillus anthracis, is highly immunogenic and protects mice against lethal challenge upon immunization. In the present study, mice were immunized with r-EA1C, the C terminal crystallization domain of EA1, to generate a neutralizing monoclonal antibody EA752 –862, that was evaluated...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
Current treatments for bladder cancer need improvement. A new study combines a growth factor with anthrax toxin to create a quick, effective treatment.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
This study evaluates the efficacy of relatively low levels of hydrogen peroxide vapor (HPV) delivered from off ‐the‐shelf equipment for the inactivation ofBacillus spores within an indoor environment. Decontamination evaluations were conducted in a house using bothBacillus atrophaeus var.globigii (Bg; as surrogates forB. anthracis) inoculated on the carpet and galvanized metal as coupons andGeobacillus stearothermophilus (Gs) as biological indicators on steel. The total decontamination time ranged from 4 to 7 days. Using the longer exposure times, low concentrations of HPV (average levels below 20 parts per million) ef...
Source: Remediation Journal - Category: Environmental Health Authors: Tags: RESEARCH ARTICLE Source Type: research
(Penn State) People who eat wildebeests, wart hogs and other wild African animals may be at risk for contracting potentially life-threatening diseases, according to an international team of researchers. The team analyzed samples of bushmeat -- meat derived from wildlife -- in the Western Serengeti in Tanzania and identified several groups of bacteria, many of which contain the species that cause diseases such as anthrax, brucellosis and Q fever.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Abstract Bacillus anthracis, the causative pathogen of anthrax, is a spore-forming, environmentally maintained bacterium that continues to be a veterinary health problem with outbreaks occurring primarily in wildlife and livestock. Globally, the genetic populations of B. anthracis include multiple lineages, and each may have different ecological requirements and geographical distributions. It is, therefore, essential to identify environmental associations within lineages to predict geographical distributions and risk areas with improved accuracy. Here, we model the ecological niche and predict the geography of the...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Tags: Am J Trop Med Hyg Source Type: research
ConclusionThe antibacterial activity of the extracts and pure compounds as reported in the reviewed literature is mostly based on in vitro assays and generally does not encourage follow up studies. The effectiveness of the reported recipes, which include fresh plant material and excipients can only be assessed through in vivo studies. Those remedies including herbal drugs with reported antimicrobial activity might have the potential as complementary therapies. The reviewed plant based antimicrobial recipes might serve as inspirations in the search for alternative topical antibacterial strategies and the search for their sy...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Chem. Commun., 2019, Advance Article DOI: 10.1039/C9CC08206A, CommunicationDai Wu, Zhe Zhang, Xiwen Chen, Lingkun Meng, Chunguang Li, Guanghua Li, Xiaobo Chen, Zhan Shi, Shouhua Feng A non-luminescent NH2-MOF-76(Eu) exhibits selective fluorescence recovery for sensing anthrax biomarker DPA through a single-crystal to single-crystal phase transition. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
A non-luminescent Eu-MOF-based "turn-on" sensor towards an anthrax biomarker through single-crystal to single-crystal phase transition. Chem Commun (Camb). 2019 Nov 26;: Authors: Wu D, Zhang Z, Chen X, Meng L, Li C, Li G, Chen X, Shi Z, Feng S Abstract A porous NH2-MOF-76(Eu) (MOF 1) with unexpected non-luminescence was designed and synthesized. It exhibits selective fluorescence recovery for sensing dipicolinic acid (DPA), a biomarker of Bacillus anthracis. Moreover, a new europium-based MOF (MOF 2) with evident channel changes was obtained through a single-crystal to single-crystal phase t...
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research
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