Activity sensors to evaluate the effect of sacubitril/valsartan on quality ‐of‐life in heart failure: rationale and design of the AWAKE‐HF study

ConclusionsThis will be the first study to assess the effects of sacubitril/valsartan on objective measures of sleep and activity in individuals with HFrEF within the context of their daily lives. Wearable accelerometer devices will be used to gain insight into how the medication affects physical activity and sleep.
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Study Design Source Type: research

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AbstractPurposePhrenic and hypoglossal nerve pacing therapies have shown benefit in sleep apnea. We sought to analyze the role of pacing therapies in sleep apnea and their impact on heart failure.MethodsA comprehensive literature search in PubMed and Google Scholar from inception to August 5, 2019, was performed. A meta-analysis was performed using fixed effects model to calculate mean difference (MD) with 95% confidence interval (CI).ResultsSix studies were eligible and included 626 patients, of whom 334 were in the control arm and 393 were in the experimental arm. Phrenic nerve pacing (MD − 23.20 events/h, 9...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
CONCLUSIONS: The prevalence of neoplasms in patients with TS is high. The clinical presentation is different in relation to patients who do not have neoplasms and they probably represent a risk factor for a worse hospital and long term prognosis. PMID: 32430206 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
We read with interest the study by Krittanawong et al “Sleep Duration and Cardiovascular Health in A Representative Community Population (from NHANES, 2005 to 2016)”.1 The authors studied 32,152 participants who responded to the sleep survey and found short sleep duration (9 hours) was also associated with higher prevalence of stroke, heart failure and coronary artery disease.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Dyspnoea, a subjective experience of breathing discomfort, is a debilitating symptom which impacts quality of life in patients with pleural effusions. It consists of a number of perceptions, including a sense of work/effort, tightness in the chest and air hunger. Dyspnoea affects up to 80% of patients with malignant pleurisy [1–3], and an even higher percentage of those with heart failure-associated effusions [4]. Pleural effusions can have a large impact, not only on breathing and quality of life [5], but also on sleep [6] and exercise capacity [7].
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory clinical practice Editorials Source Type: research
We examined baseline stress, sleep disturbance, and sleep-related characteristics from a randomized controlled trial of cognitive behavioral therapy for insomnia, including the Perceived Stress Scale, Insomnia Severity Index, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Sleep Disturbance Questionnaire, Dysfunctional Beliefs about Sleep Scale, PROMIS Cognitive Ability, SF-36 Mental Health, and wrist actigraphy. We used Pearson correlations and general linear models to assess stress-sleep associations, including the potential moderating effects of sex and symptom severity (NYHA).Results: There were moderate-to-l...
Source: Behavioral Sleep Medicine - Category: Sleep Medicine Authors: Tags: Behav Sleep Med Source Type: research
Dr. Lee and Kevin Craig, MD, diagnose a 66-year-old woman with hemoptysis, shortness of breath, and afib who is on Eliquis and has hypertension, congestive heart failure, an implantable cardioverter defibrillator, and sleep apnea. Watch this video to hear their plan for her care.
Source: Emergency Medicine News - Video - Category: Databases & Libraries Source Type: video
In conclusion, our study demonstrated that Nrf2 deficiency promoted the increasing trend of autophagy during aging in skeletal muscle. Nrf2 deficiency and increasing age may cause excessive autophagy in skeletal muscle, which can be a potential mechanism for the development of sarcopenia. To What Degree is Chondrocyte Hypertrophy in Osteoarthritis Due to Cellular Senescence? https://www.fightaging.org/archives/2020/04/to-what-degree-is-chondrocyte-hypertrophy-in-osteoarthritis-due-to-cellular-senescence/ Senescent cells are large. They do not replicate, that function is disabled, but it is as if they go ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined the relation between sleep duration and cardiovascular health among the general population in the United States from 2005 to 2016. We sought to investigate associations between sleep duration and the prevalence of coronary artery disease (CAD), heart failure (HF), stroke, hypertension, diabetes mellitus (DM), and hyperlipidemia.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
r Harst P, Juarez-Orozco LE Abstract BACKGROUND: Obstructive sleep apnea (OSA) conveys worse clinical outcomes in coronary artery disease patients. The STOP-BANG score is a simple tool that evaluates the risk of OSA and can be added to the large number of clinical variables and scores obtained during the management of myocardial infarction (MI) patients. Currently, machine learning (ML) is able to select and integrate numerous variables to optimize prediction tasks. RESEARCH QUESTION: Can the integration of STOP-BANG score with clinical data and scores through ML better identify patients who suffered an in-ho...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
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