Pentraxin 3 deficiency protects from the metabolic inflammation associated to diet-induced obesity

ConclusionOur results support a critical role for PTX3 in the onset of obesity by promoting inflammation and limiting adipose tissue vascularization and delineate PTX3 targeting as a valuable strategy for the treatment of adipose tissue-associated inflammatory response.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSION: Metabolic health status and obesity were significantly associated with increased risk of POAG incidence. MUNO subjects but not MHO subjects showed a higher risk of POAG development than did MHNO subjects, suggesting that metabolic status is more important than obesity in POAG. PMID: 31950773 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
The objective of this study was to investigate the association between the genetic variants of the ADIPOQ gene (+45T>G and +276G>T) with MetS among a relocated indigenous Temiar subtribe community in Malaysia. This cross-sectional study investigated 123 relocated Temiar volunteers in Kelantan. Modified NCEP ATP III criteria were used to diagnose MetS. DNA was extracted from peripheral blood and genotyped for ADIPOQ +45T>G and +276G>T polymorphisms using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique. Associations between ADIPOQ +45T>G (rs2241766) and +276G>T (rs150...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
Conclusion: PsA is characterized by an increase in cardiovascular morbidity in relation with insulin resistance. Current treatments seem to improve this risk with a decrease in cardiovascular mortality in comparison with patients with plaque psoriasis but this requires confirmation in larger prospective studies.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
ConclusionsThe findings of this study indicate high prevalence of metabolic risk factors among study population. This study with a large sample size would contribute to establishment of efficient interventions and programs aimed at reducing the prevalence of MetS by health staff, supervisors and policymakers.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionKappa coefficient showed that the Iranian IDF had a good agreement with International IDF and an intermediate agreement with the ATP-III. Considering more emphasis of international and Iranian IDF on waist circumference (WC), a better agreement between these two criteria is plausible. Regarding the high prevalence of abdominal obesity among Iranian population, applying these criteria to identify high risk persons might be helpful.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
(Natural News) Years of research have established a positive collaboration between estrogen and vitamin D to improve bone health. Now, recent research suggests that this dynamic duo could also play a role in staving off metabolic syndrome in postmenopausal women. Metabolic syndrome is described as a cluster of conditions – such as obesity, high blood...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusion This study demonstrates an increased risk for all-cause disability pension, even after adjustment for other risk factors, among Swedish employees with metabolic syndrome compared to those withou t at baseline.byLid én E, Karlsson B, Torén K, Andersson E. doi:10.5271/sjweh.3883
Source: Scandinavian Journal of Work, Environment and Health - Category: Occupational Health Tags: Original article Source Type: research
CONCLUSIONS: We have shown that disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice. PMID: 31941380 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
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