The environment, epigenetic landscape and cardiovascular risk

Cardiovascular disease (CVD) is the most common non-communicable disease worldwide. Future projections predict an increasing CVD burden due to aging, urbanization, and unhealthy lifestyles with devastating socio-economic implications in emerging countries. Despite implementation of traditional risk score models and state-of-the-art treatment strategies, CVD is far from being eradicated. Atherothrombosis underlies the majority of CV events and mostly develops from unforeseeable disruption of atheromatous plaque with subsequent platelet activation and thrombus formation. This condition is triggered by the derail of molecular pathways involved in oxidative stress, inflammatory changes and endothelial dysfunction. CV risk phenotype is extremely heterogeneous and the development/progression of CVD depends on aging, environmental, and genetic factors.1 However, gene –environment interaction only partially explains the phenotypic variability of CV risk, suggesting that other mechanisms play an important role. In this perspective, a growing body of evidence supports the notion that epigenetics variations, linking the environment to long-lasting effects on the p henotype, are a key mechanism of increased CV risk (Figure 1).
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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We report a young woman with a life-threatening basilar artery thrombosis during sexual intercourse, with a resulting locked-in syndrome. The positive high intensity transient signals (HITS) diagnosis showed a right-to-left shunt and is in line with paradoxic embolism. The molecular genetics revealed a homozygosity 4G/4G in the region PAI1, -675 (promoter polymorphism) as a risk factor for ischemic stroke. Sexual intercourse is a possible, albeit unusual stroke cause, especially in young people.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 23 January 2020Source: The Annals of Thoracic SurgeryAuthor(s): Malak Elbatarny, Derrick Y. Tam, J. James Edelman, Rodolfo V. Rocha, Michael W.A. Chu, Mark D. Peterson, Ismail El-Hamamsy, Jehangir J. Appoo, Jan O. Friedrich, Munir Boodhwani, Bobby Yanagawa, Maral Ouzounian, Canadian Thoracic Aortic Collaborative (CTAC) InvestigatorsAbstractBackgroundAortic valve sparing operations theoretically have fewer stroke and bleeding complications but may increase late reoperation risk, versus composite valve grafts.MethodsWe meta-analyzed all studies comparing aortic valve sparing (reimplantation...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 22 January 2020Source: Life SciencesAuthor(s): Changzhe Chen, Chenxi Song, Dong Zhang, Dong Yin, Rui Zhang, Jingzhou Chen, Kefei DouAbstractAimsTo explore whether the combination of atorvastatins and resveratrol is superior to each individual drug alone regarding re-endothelialization after drug-eluting stents (DESs) implantation.Materials and methodsNinety-four rabbits were randomized into control, atorvastatin, resveratrol, and combined medication groups. Abdominal aorta injury was induced via ballooning, followed by DES implantation. Neointimal formation and re-endothelialization after...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 22 January 2020Source: Journal of Vascular and Interventional RadiologyAuthor(s): Mina S. Makary, Brian D. Fogler, Priyanka P. Dube, Vince L. Flanders, Kannan Natarajan, Rafael Garcia-Cortes, Todd Foster, Joshua D. DowellAbstractPurposeTo evaluate ultrasound-accelerated, catheter-directed thrombolysis (CDT) for treatment of acute submassive pulmonary embolism (PE).Materials and MethodsThis single-center, retrospective study included patients who underwent CDT for acute submassive PE (N = 113, 52% men/48% women) from 2013 to 2017. Baseline characteristics included history of deep veno...
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsThe JETi8 system may be a safe and effective option for thrombectomy of acute DVT.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
This study also examines the clinical nurse's role in preventing thrombosis and caring for pediatric patients who present with thrombosis. METHODS: The thrombosis literature was reviewed to identify risk factors, treatment regimens, and strategies for prevention. FINDINGS: Thrombosis in pediatric patients with cancer requires management of potential complications so that cancer treatment may continue. PMID: 31961846 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
harbe Zacconi The coagulation cascade is the process of the conversion of soluble fibrinogen to insoluble fibrin that terminates in production of a clot. Factor Xa (FXa) is a serine protease involved in the blood coagulation cascade. Moreover, FXa plays a vital role in the enzymatic sequence which ends with the thrombus production. Thrombosis is a common causal pathology for three widespread cardiovascular syndromes: acute coronary syndrome (ACS), venous thromboembolism (VTE), and strokes. In this research a series of N-propargyltetrahydroquinoline and 1,2,3-triazole derivatives as a potential factor Xa (FXa) inhibi...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionIn 20% of failing MT, thrombus cannot be reached/passed. Direct carotid puncture or surgical arterial access could be considered in these cases.In 80% of failing interventions, thrombus can be passed with the device, but the occluded vessel cannot be recanalized. Rescue techniques can be an option. Development of new devices and techniques is necessary to improve recanalization rates. Assessment of pre-existing illness could sensitize for occurring complications.
Source: Neurological Sciences - Category: Neurology Source Type: research
Authors: Mohandes M, Pernigotti A, Morr CI, Bardají A PMID: 31960636 [PubMed - as supplied by publisher]
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
Publication date: Available online 22 January 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Giuseppe De Luca, Monica Verdoia, Stefano Savonitto, Luca A. Ferri, Luigi Piatti, Daniele Grosseto, Nuccia Morici, Irene Bossi, Paolo Sganzerla, Giovanni Tortorella, Michele Cacucci, Maurizio Ferrario, Ernesto Murena, Girolamo Sibilio, Stefano Tondi, Anna Toso, Sergio Bongioanni, Amelia Ravera, Elena Corrada, Matteo MarianiAbstractBackgroundElderly patients are at increased risk of hemorrhagic and thrombotic complications after an acute coronary syndrome (ACS). Frailty, comorbilities and low body weight hav...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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